Stability crossing boundaries of delay systems modeling immune dynamics in leukemia

DOI10.3934/DCDSB.2010.13.129MaRDI QIDQ2654524zbMATH OpenOpenAlexFDO

Authors Keqin Gu, Peter P. Lee, Doron Levy, Silviu-Iulian Niculescu, Peter S. Kim

Publication date 19 January 2010

Published in Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL https://doi.org/10.3934/dcdsb.2010.13.129

zbMATH Keywords

asymptotic stabilitycrossing curvesdelayleukemia modelsquasipolynomialreversalswitch

Mathematics Subject Classification ID

Stability theory of functional-differential equations (34K20) Qualitative investigation and simulation of models involving functional-differential equations (34K60) Medical applications (general) (92C50)

Review text

This paper focuses on the characterization of delay effects on the asymptotic stability of some continuous-time delay systems encountered in modeling the post-transplantation dynamics of the immune response to chronic myelogenous leukemia. Such models include multiple delays in some large range, from one minute to several days. The main objective of the paper is to study the stability of the crossing boundaries of the corresponding linearized models in the delay-parameter space by taking into account the interactions between small and large delays. Weak and strong cell interactions are discussed and analytic characterizations are proposed. An illustrative example together with related discussions completes the presentation.

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Cited in

(10)

• Bifurcation analysis in a diffusive logistic population model with two delayed density-dependent feedback terms
• Extraction of 3D stability switching hypersurfaces of a time delay system with multiple fixed delays
• Hopf bifurcation in a reaction-diffusion-advection model with two nonlocal delayed density-dependent feedback terms
• Analysis of a new model of cell population dynamics in Acute Myeloid Leukemia
• Local Asymptotic Stability Conditions for the Positive Equilibrium of a System Modeling Cell Dynamics in Leukemia
• Analysis of HIV models with two time delays
• Diffusive spatial movement with memory and maturation delays
• Stability switches in a logistic population model with mixed instantaneous and delayed density dependence
• Stability of an Imatinib and immune model with delays
• Stability Analysis of a Feedback Model for the Action of the Immune System in Leukemia

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Uses Software

• DDE-BIFTOOL

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