Multiple testing for neuroimaging via hidden Markov random field

DOI10.1111/BIOM.12329zbMATH Open1419.62446arXiv1404.1371OpenAlexW3123277272WikidataQ36084834 ScholiaQ36084834MaRDI QIDQ2803494FDOQ2803494

Authors: Hai Shu, Bin Nan, Robert Koeppe 

Publication date: 4 May 2016

Published in: Biometrics (Search for Journal in Brave)

Abstract: Traditional voxel-level multiple testing procedures in neuroimaging, mostly $p$-value based, often ignore the spatial correlations among neighboring voxels and thus suffer from substantial loss of power. We extend the local-significance-index based procedure originally developed for the hidden Markov chain models, which aims to minimize the false nondiscovery rate subject to a constraint on the false discovery rate, to three-dimensional neuroimaging data using a hidden Markov random field model. A generalized expectation-maximization algorithm for maximizing the penalized likelihood is proposed for estimating the model parameters. Extensive simulations show that the proposed approach is more powerful than conventional false discovery rate procedures. We apply the method to the comparison between mild cognitive impairment, a disease status with increased risk of developing Alzheimer's or another dementia, and normal controls in the FDG-PET imaging study of the Alzheimer's Disease Neuroimaging Initiative.

Full work available at URL: https://arxiv.org/abs/1404.1371

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zbMATH Keywords

false discovery ratepenalized likelihoodAlzheimer's diseaseIsing modelgeneralized expectation-maximization algorithmlocal significance index

Mathematics Subject Classification ID

Random fields; image analysis (62M40) Applications of statistics to biology and medical sciences; meta analysis (62P10) Paired and multiple comparisons; multiple testing (62J15)

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Cited In (20)

• Multiple testing in genome-wide association studies via hierarchical hidden Markov models
• Spatially dependent multiple testing under model misspecification, with application to detection of anthropogenic influence on extreme climate events
• Large-scale multiple testing via multivariate hidden Markov models
• Large-scale dependent multiple testing via hidden semi-Markov models
• Effect-size estimation using semiparametric hierarchical mixture models in disease-association studies with neuroimaging data
• Controlling the familywise error rate in functional neuroimaging: a comparative review
• Multiscale adaptive regression models for neuroimaging data
• Robust spatial extent inference with a semiparametric bootstrap joint inference procedure
• LAWS: A Locally Adaptive Weighting and Screening Approach to Spatial Multiple Testing
• Statistical disease mapping for heterogeneous neuroimaging studies
• Extended likelihood approach to multiple testing with directional error control under a hidden Markov random field model
• False Discovery Rate Smoothing
• Multiple Testing Correction in Medical Image Analysis
• Covariate-modulated large-scale multiple testing under dependence
• A peeling algorithm for multiple testing on a random field
• Covariate-adjusted multiple testing in genome-wide association studies via factorial hidden Markov models
• Bayesian hidden Markov models for dependent large-scale multiple testing
• Hidden Markov model in multiple testing on dependent count data
• Interpretable high-dimensional inference via score projection with an application in neuroimaging
• Multiple testing via \(\mathrm{FDR}_L\) for large-scale imaging data

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