Mixed-mode oscillations and interspike interval statistics in the stochastic FitzHugh-Nagumo model

DOI10.1088/0951-7715/25/8/2303zbMATH Open1248.60059arXiv1105.1278OpenAlexW3106501297MaRDI QIDQ2905063FDOQ2905063

Authors: Nils Berglund, Damien Landon 

Publication date: 24 August 2012

Published in: Nonlinearity (Search for Journal in Brave)

Abstract: We study the stochastic FitzHugh-Nagumo equations, modelling the dynamics of neuronal action potentials, in parameter regimes characterised by mixed-mode oscillations. The interspike time interval is related to the random number of small-amplitude oscillations separating consecutive spikes. We prove that this number has an asymptotically geometric distribution, whose parameter is related to the principal eigenvalue of a substochastic Markov chain. We provide rigorous bounds on this eigenvalue in the small-noise regime, and derive an approximation of its dependence on the system's parameters for a large range of noise intensities. This yields a precise description of the probability distribution of observed mixed-mode patterns and interspike intervals.

Full work available at URL: https://arxiv.org/abs/1105.1278

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zbMATH Keywords

stochastic FitzHugh-Nagumo modelasymptotically geometric distributiondynamics of neuronal action potentialsnumber of small-amplitude oscillations separating consecutive spikes

Mathematics Subject Classification ID

Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Neural biology (92C20) Stochastic ordinary differential equations (aspects of stochastic analysis) (60H10) Relaxation oscillations for ordinary differential equations (34C26)

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