Using dynamic perturbations to identify fragilities in biochemical networks

DOI10.1002/RNC.1590zbMATH Open1298.93234OpenAlexW2027812535MaRDI QIDQ2928348FDOQ2928348

Authors: Elling W. Jacobsen, Camilla Trane 

Publication date: 7 November 2014

Published in: International Journal of Robust and Nonlinear Control (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/rnc.1590

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zbMATH Keywords

robustnessbifurcationsbiochemical reaction networks

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Sensitivity (robustness) (93B35) Large-scale systems (93A15) Perturbations in control/observation systems (93C73)

Cites Work

• Mathematical Systems Theory I
• The complex structured singular value
• Practical bifurcation and stability analysis: from equilibrium to chaos.

Cited In (6)

• Robust multi-drug therapy design and application to insulin resistance in type 2 diabetes
• Propagation of extrinsic perturbation in multistep biochemical pathways
• Bifurcation analysis of a biochemical network
• Eigenvalue sensitivity-based analysis for evaluation of biological network stability versus disturbances
• Analysis of autocatalytic networks in biology
• Detection of synergistic combinatorial perturbations by a bifurcation-based approach

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