Using dynamic perturbations to identify fragilities in biochemical networks

DOI10.1002/RNC.1590MaRDI QIDQ2928348zbMATH OpenOpenAlexFDO

Authors Elling W. Jacobsen, Camilla Trane

Publication date 7 November 2014

Published in International Journal of Robust and Nonlinear Control (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/rnc.1590

zbMATH Keywords

robustnessbifurcationsbiochemical reaction networks

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Sensitivity (robustness) (93B35) Large-scale systems (93A15) Perturbations in control/observation systems (93C73)

Recommendations

• Bifurcation analysis of a biochemical network
• Analysis and extension of a biochemical network model using robust control theory
• Robust stability and instability of biochemical networks with parametric uncertainty
• Control theory and systems biology.
• Analysis of autocatalytic networks in biology

Cites work

• Mathematical Systems Theory I
• Practical bifurcation and stability analysis: from equilibrium to chaos.
• The complex structured singular value

Cited in

(6)

• Robust multi-drug therapy design and application to insulin resistance in type 2 diabetes
• Analysis of autocatalytic networks in biology
• Propagation of extrinsic perturbation in multistep biochemical pathways
• Eigenvalue sensitivity-based analysis for evaluation of biological network stability versus disturbances
• Detection of synergistic combinatorial perturbations by a bifurcation-based approach
• Bifurcation analysis of a biochemical network

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