Curve-Free and Model-Based Continual Reassessment Method Designs

DOI10.1111/j.0006-341X.2002.00245.xzbMath1209.62318OpenAlexW2100912875WikidataQ45935252 ScholiaQ45935252MaRDI QIDQ3078936

John O'Quigley

Publication date: 1 March 2011

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.0006-341x.2002.00245.x

zbMATH Keywords

clinical trialsmaximum tolerated dosedose findingphase I designscurve-free continual reassessment method

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Related Items

Adaptive clinical trial designs for phase I cancer studies ⋮ Up-and-down experiments of first and second order ⋮ The Continual Reassessment Method for Multiple Toxicity Grades: A Bayesian Quasi‐Likelihood Approach ⋮ The Continual Reassessment Method for Multiple Toxicity Grades: A Bayesian Quasi‐Likelihood Approach ⋮ Simulation of clinical trials: a review with emphasis on the design issues ⋮ Randomized group up and down experiments

Cites Work

• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Consistency of continual reassessment method under model misspecification
• Continual Reassessment Method: A Likelihood Approach
• A Curve‐Free Method for Phase I Clinical Trials