Mass concentration in a nonlocal model of clonal selection
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Publication:329376
DOI10.1007/S00285-016-0979-3zbMATH Open1360.92035arXiv1401.6043OpenAlexW2110818097WikidataQ37245945 ScholiaQ37245945MaRDI QIDQ329376FDOQ329376
Jan-Erik Busse, Anna Marciniak-Czochra, Piotr Gwiazda
Publication date: 21 October 2016
Published in: Journal of Mathematical Biology (Search for Journal in Brave)
Abstract: Self-renewal is a constitutive property of stem cells. Testing the cancer stem cell hypothesis requires investigation of the impact of self-renewal on cancer expansion. To understand better this impact, we propose a mathematical model describing dynamics of a continuum of cell clones structured by the self-renewal potential. The model is an extension of the finite multi-compartment models of interactions between normal and cancer cells in acute leukemias. It takes a form of a system of integro-differential equations with a nonlinear and nonlocal coupling, which describes regulatory feedback loops in cell proliferation and differentiation process. We show that such coupling leads to mass concentration in points corresponding to maximum of the self-renewal potential and the model solutions tend asymptotically to a linear combination of Dirac measures. Furthermore, using a Lyapunov function constructed for a finite dimensional counterpart of the model, we prove that the total mass of the solution converges to a globally stable equilibrium. Additionally, we show stability of the model in space of positive Radon measures equipped with flat metric. The analytical results are illustrated by numerical simulations.
Full work available at URL: https://arxiv.org/abs/1401.6043
integro-differential equationsLyapunov functionmass concentrationbounded Lipschitz distancecell differentiation modelclonal evolutionselection process
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Cited In (18)
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