ON THE RELATION BETWEEN FLUCTUATION AND SCALING-LAW IN GENE EXPRESSION TIME SERIES FROM YEAST TO HUMAN

DOI10.1142/S0217984905009249MaRDI QIDQ3373052zbMATH OpenOpenAlexFDO

Authors J. C. Nacher, T. Ochiai, Tatsuya Akutsu

Publication date 13 March 2006

Published in Modern Physics Letters B (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0503004

zbMATH Keywords

self-organizationgene expressionstochastic processbiodynamics

Mathematics Subject Classification ID

Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Biochemistry, molecular biology (92C40) Genetics and epigenetics (92D10) Stochastic ordinary differential equations (aspects of stochastic analysis) (60H10)

Abstract: In this work, the dynamics of fluctuations in gene expression time series is investigated. By using collected data of gene expression from yeast and human organisms, we found that the fluctuations of gene expression level and its average value over time are strongly correlated and obey a scaling law. As this feature is found in yeast and human organisms, it suggests that probably this coupling is a common dynamical organizing property of all living systems. To understand these observations, we propose a stochastic model which can explain these collective fluctuations, and predict the scaling exponent. Interestingly, our results indicate that the observed scaling law emerges from the self-similarity symmetry embedded in gene expression fluctuations.

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Cites work

• scientific article; zbMATH DE number 3806623 (Why is no real title available?)
• scientific article; zbMATH DE number 3388297 (Why is no real title available?)
• A constructive approach to gene expression dynamics
• A stochastic approach to multi-gene expression dynamics

Cited in

(3)

• Power-law distribution of gene expression fluctuations
• Informed generation: physical origin and biological evolution of genetic codescript interpreters
• Fluctuation scaling in neural spike trains

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