Optimization of spatial control strategies for population replacement, application toWolbachia

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Publication:3383282

DOI10.1051/COCV/2021070zbMATH Open1471.92250arXiv2012.04275OpenAlexW3173314530MaRDI QIDQ3383282FDOQ3383282


Authors: Michel Duprez, Romane Hélie, Yannick Privat, Nicolas Vauchelet Edit this on Wikidata


Publication date: 23 September 2021

Published in: ESAIM: Control, Optimisation and Calculus of Variations (Search for Journal in Brave)

Abstract: In this article, we are interested in the analysis and simulation of solutions to an optimal control problem motivated by population dynamics issues. In order to control the spread of mosquito-borne arboviruses, the population replacement technique consists in releasing into the environment mosquitoes infected with the Wolbachia bacterium, which greatly reduces the transmission of the virus to the humans. Spatial releases are then sought in such a way that the infected mosquito population invades the uninfected mosquito population. Assuming very high mosquito fecundity rates, we first introduce an asymptotic model on the proportion of infected mosquitoes and then an optimal control problem to determine the best spatial strategy to achieve these releases. We then analyze this problem, including the optimality of natural candidates and carry out first numerical simulations in one dimension of space to illustrate the relevance of our approach.


Full work available at URL: https://arxiv.org/abs/2012.04275




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