A robust optimization approach to experimental design for model discrimination of dynamical systems
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Publication:378083
DOI10.1007/S10107-012-0532-0zbMATH Open1280.62092arXiv1101.3663OpenAlexW2045534984MaRDI QIDQ378083FDOQ378083
Authors: Dominik Skanda, Dirk Lebiedz 
Publication date: 11 November 2013
Published in: Mathematical Programming. Series A. Series B (Search for Journal in Brave)
Abstract: A high-ranking goal of interdisciplinary modeling approaches in the natural sciences are quantitative prediction of system dynamics and model based optimization. For this purpose, mathematical modeling, numerical simulation and scientific computing techniques are indispensable. Quantitative modeling closely combined with experimental investigations is required if the model is supposed to be used for sound mechanistic analysis and model predictions. Typically, before an appropriate model of a experimental system is found different hypothetical models might be reasonable and consistent with previous knowledge and available data. The parameters of the model up to an estimated confidence region are generally not known a priori. Therefore one has to incorporate possible parameter configurations of different models into a model discrimination algorithm. In this article we present a numerical algorithm which calculates a design of experiments which allows an optimal discrimination of different hypothetic candidate models of a given dynamic system for the most inappropriate parameter configurations within a parameter range via a worst case estimate. The design criterion comprises optimal measurement time points. The used criterion is derived from the Kullback-Leibler divergence. The underlying optimization problem can be classified as a semi infinite optimization problem which we solve in an outer approximation approach stabilized by a homotopy strategy. We present the theoretical framework as well as the numerical algorithmic realization.
Full work available at URL: https://arxiv.org/abs/1101.3663
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Optimal statistical designs (62K05) Applications of mathematical programming (90C90) Semi-infinite programming (90C34)
Cites Work
- On the implementation of an interior-point filter line-search algorithm for large-scale nonlinear programming
- Model Selection and Multimodel Inference
- Optimization. Algorithms and consistent approximations
- Title not available (Why is that?)
- Semi-Infinite Programming: Theory, Methods, and Applications
- Title not available (Why is that?)
- Title not available (Why is that?)
- Necessary conditions for min-max problems and algorithms by a relaxation procedure
- On the use of consistent approximations in the solution of semi-infinite optimization and optimal control problems
- A Polyalgorithm for the Numerical Solution of Ordinary Differential Equations
- Title not available (Why is that?)
- The design of experiments for discriminating between two rival models
- An Optimal Experimental Design Criterion for Discriminating Between Non-Normal Models
- Robust experiment design via maximin optimization
- On the change of step size in multistep codes
- Numerical methods for optimum experimental design in DAE systems
- Adjoint-based algorithms and numerical methods for sensitivity generation and optimization of large scale dynamic systems.
- Large-Sample Theory: Parametric Case
- Construction of T-optimum designs for multiresponse dynamic models
- Algorithm differentiation of implicit functions and optimal values
- Homotopy curve tracking in approximate interior point optimization
- Title not available (Why is that?)
- MODELING THE NONLINEAR DYNAMICS OF CELLULAR SIGNAL TRANSDUCTION
- Title not available (Why is that?)
- Title not available (Why is that?)
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- Optimal design of validation experiments for the prediction of quantities of interest
- Optimal input design for model discrimination using Pontryagin's maximum principle: application to kinetic model structures
- Optimum experimental designs for dynamic systems in the presence of correlated errors
- Prediction uncertainty and optimal experimental design for learning dynamical systems
- Robust optimal experimental design for model discrimination of kinetic ODE systems
- Robust System Design with Limited Experimental Data and an Inexact Simulation Model
- Robustness aspects in parameter estimation, optimal design of experiments and optimal control
- Experiment selection for the discrimination of semi-quantitative models of dynamical systems
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- Robust Optimality and Duality in Multiobjective Optimization Problems under Data Uncertainty
- Quasiconvexity of set-valued maps assures well-posedness of robust vector optimization
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