The role of backward mutations on the within-host dynamics of HIV-1

DOI10.1007/s00285-012-0581-2zbMath1278.92028WikidataQ37007926 ScholiaQ37007926MaRDI QIDQ378292

Roberto A. Saenz, John M. Kitayimbwa, Joseph Y. T. Mugisha

Publication date: 11 November 2013

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc4909148

zbMATH Keywords

drug resistance; within-host model; virus mutations

Mathematics Subject Classification ID

37N25: Dynamical systems in biology

92C60: Medical epidemiology

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Cites Work

• Unnamed Item
• Applications of centre manifold theory
• Dynamical models of tuberculosis and their applications
• Dynamics of HIV infection of CD4\(^ +\) T cells
• Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission
• Emergence of HIV-1 drug resistance during antiretroviral treatment
• Drug concentration heterogeneity facilitates the evolution of drug resistance
• Production of resistant HIV mutants during antiretroviral therapy