Modeling synthetic gene oscillators

DOI10.1016/J.MBS.2012.01.001MaRDI QIDQ419382zbMATH OpenOpenAlexWikidataFDO

Authors Erin L. O'Brien, Elizabeth Van Itallie, Matthew R. Bennett

Publication date 18 May 2012

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2012.01.001

zbMATH Keywords

delaysynthetic biologygene networkstranscriptional regulation

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Genetics and epigenetics (92D10) Systems biology, networks (92C42)

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Cites work

• A generalized model of the repressilator
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• From Kuramoto to Crawford: Exploring the onset of synchronization in population of coupled oscillators
• Huygens's clocks
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• Mathematical biology. Vol. 1: An introduction.
• Modeling a synthetic multicellular clock: Repressilators coupled by quorum sensing
• Modeling transcriptional control in gene networks -- methods, recent results, and future directions
• Quasi-steady state assumptions for non-isolated enzyme-catalysed reactions
• Stochastic delay differential equations for genetic regulatory networks
• Studying genetic regulatory networks at the molecular level: delayed reaction stochastic models
• Synchronization of electronic genetic networks
• Synchronization: a universal concept in nonlinear sciences
• The role of dimerization in noise reduction of simple genetic networks
• Transient dynamics around unstable periodic orbits in the generalized repressilator model

Cited in

(15)

• Chaos in gene regulatory networks: effects of time delays and interaction structure
• Spatial-stochastic modelling of synthetic gene regulatory networks
• Spatiotemporal dynamics of distributed synthetic genetic circuits
• Nonlinear dynamics of synthetic gene regulatory circuits
• Stability analysis of an artificial biomolecular oscillator with non-cooperative regulatory interactions
• Theoretical and experimental analysis of the forced LacI-AraC oscillator with a minimal gene regulatory model
• Long negative feedback loop enhances period tunability of biological oscillators
• Computational modelling of cancer development and growth: modelling at multiple scales and multiscale modelling
• Synchronization analysis for a class of genetic oscillator networks
• A general principle for spontaneous genetic symmetry breaking and pattern formation within cell populations
• Spatio-temporal models of synthetic genetic oscillators
• How to couple identical ring oscillators to get quasiperiodicity, extended chaos, multistability, and the loss of symmetry
• The effects of time-varying temperature on delays in genetic networks
• Engineering a genetic oscillator using delayed feedback
• Modeling the effect of cell division on genetic oscillators

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