Role of CD4^+ T-cell proliferation in HIV infection under antiretroviral therapy

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Publication:442473





The authors study a mathematical model describing the interaction between HIV viruses and CD4+ T cells. Both RT and protease inhibitor treatments are incorporated in the model. They assume that the CD4+ T cells proliferate according to a saturation form which is different from the commonly used logistic proliferation form in the literature. Both local and global analyses are carried out. A backward bifurcation has been observed. The global stability of the unique infected equilibrium has been established by using a new criterion developed by M.Y. Li and J.S. Muldowney which has been successfully utilized by some researchers for some high dimensional systems.



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