On the inefficiency of the adaptive design for monitoring clinical trials

DOI10.1093/BIOMET/90.2.367MaRDI QIDQ4455417zbMATH OpenOpenAlexFDO

Authors Anastasios A. Tsiatis, Cyrus R. Mehta

Publication date 16 March 2004

Published in Biometrika (Search for Journal in Brave)

Full work available at URL https://semanticscholar.org/paper/b872af483adb03dfa91262ca4f20af3751dc63ea

zbMATH Keywords

likelihood ratio testadaptive designoptimal group-sequential tests

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical analysis (62L10)

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Cited in

(20)

• Generalized Likelihood Ratio Statistics and Uncertainty Adjustments in Efficient Adaptive Design of Clinical Trials
• Bandit Theory: Applications to Learning Healthcare Systems and Clinical Trials
• Benefit–Risk Evaluation of Multi-Stage Adaptive Designs
• Statistical Inference for Self‐Designing Clinical Trials with a One‐Sided Hypothesis
• Adaptive and nonadaptive group sequential tests
• Sample size adaptation designs and efficiency comparison with group sequential designs
• Two-stage randomized clinical trials with a right-censored endpoint: comparison of frequentist and Bayesian adaptive designs
• Monitoring Accumulating Data in a Clinical Trial
• On the efficiency of adaptive designs for flexible interim decisions in clinical trials
• On the efficiency of adaptive sample size design
• Optimal planning of adaptive two-stage designs
• Adaptive randomized trial designs that cannot be dominated by any standard design at the same total sample size
• Sample size re-estimation for confirmatory two-stage flexible multi-arm trial with normal outcomes
• Optimal adaptive promising zone designs
• Internal pilots for observational studies
• Are Flexible Designs Sound?
• Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications
• Flexible Designs for Genomewide Association Studies
• Designing a longitudinal clinical trial based on a composite endpoint: sample size, monitoring, and adaptation
• α-Investing: a Procedure for Sequential Control of Expected False Discoveries

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