On the inefficiency of the adaptive design for monitoring clinical trials

DOI10.1093/biomet/90.2.367zbMath1034.62069OpenAlexW2048014796MaRDI QIDQ4455417

Cyrus R. Mehta, Anastasios A. Tsiatis

Publication date: 16 March 2004

Published in: Biometrika (Search for Journal in Brave)

Full work available at URL: https://semanticscholar.org/paper/b872af483adb03dfa91262ca4f20af3751dc63ea

zbMATH Keywords

likelihood ratio testadaptive designoptimal group-sequential tests

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical analysis (62L10)

Related Items (10)

Benefit–Risk Evaluation of Multi-Stage Adaptive Designs ⋮ Flexible Designs for Genomewide Association Studies ⋮ Bandit Theory: Applications to Learning Healthcare Systems and Clinical Trials ⋮ Sample size re-estimation for confirmatory two-stage flexible multi-arm trial with normal outcomes ⋮ Generalized Likelihood Ratio Statistics and Uncertainty Adjustments in Efficient Adaptive Design of Clinical Trials ⋮ α-Investing: a Procedure for Sequential Control of Expected False Discoveries ⋮ On the efficiency of adaptive designs for flexible interim decisions in clinical trials ⋮ Internal pilots for observational studies ⋮ Are Flexible Designs Sound? ⋮ Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications

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