scientific article; zbMATH DE number 1463367

Ordinary differential equations with impulses (34A37) Periodic solutions to ordinary differential equations (34C25) Structural stability and analogous concepts of solutions to ordinary differential equations (34D30) General biology and biomathematics (92B05) Cell biology (92C37)

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The authors study the nonlinear impulse differential equations in the plane \[ \begin{aligned} &\dot x_1= F_1(x_1,x_2),\quad \dot x_2= F_2(x_1,x_2),\\ &x_1(t^+_i)= \theta_1(x_1(t_i), x_2(t_i)),\quad x_2(t^+_i)= \theta_2(x_1(t_i), x_2(t_i)),\end{aligned}\tag{1} \] with \(t_{i+1}- t_i= \tau> 0\), \(i= 0,1,2,\dots\), \(x_1,x_2\in \mathbb{R}\), \(\theta_1\), \(\theta_2\) two positive, suitably smooth functions of \(x_1\): normal cell biomass and \(x_2\): tumor cell biomass. They describe the competition between normal and tumor cells. Sufficient conditions for the existence of nontrivial, periodic solutions to (1) are given.

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