Causal inference through potential outcomes and principal stratification: application to studies with ``censoring due to death
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Publication:449724
DOI10.1214/088342306000000114zbMATH Open1246.62198arXivmath/0612783OpenAlexW2022439966WikidataQ130494099 ScholiaQ130494099MaRDI QIDQ449724FDOQ449724
Authors: Donald B. Rubin 
Publication date: 1 September 2012
Published in: Statistical Science (Search for Journal in Brave)
Abstract: Causal inference is best understood using potential outcomes. This use is particularly important in more complex settings, that is, observational studies or randomized experiments with complications such as noncompliance. The topic of this lecture, the issue of estimating the causal effect of a treatment on a primary outcome that is ``censored by death, is another such complication. For example, suppose that we wish to estimate the effect of a new drug on Quality of Life (QOL) in a randomized experiment, where some of the patients die before the time designated for their QOL to be assessed. Another example with the same structure occurs with the evaluation of an educational program designed to increase final test scores, which are not defined for those who drop out of school before taking the test. A further application is to studies of the effect of job-training programs on wages, where wages are only defined for those who are employed. The analysis of examples like these is greatly clarified using potential outcomes to define causal effects, followed by principal stratification on the intermediated outcomes (e.g., survival).
Full work available at URL: https://arxiv.org/abs/math/0612783
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Censored data models (62N01) Applications of statistics to biology and medical sciences; meta analysis (62P10)
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Cited In (28)
- Longitudinal data with follow-up truncated by death: match the analysis method to research aims
- A mixed model approach to estimate the survivor average causal effect in cluster-randomized trials
- Causal inference: a missing data perspective
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- Evaluating the Effect of Training on Wages in the Presence of Noncompliance, Nonemployment, and Missing Outcome Data
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