Modification of Sample Size in Group Sequential Clinical Trials

DOI10.1111/J.0006-341X.1999.00853.XzbMath1059.62636OpenAlexW2088238660WikidataQ47213272 ScholiaQ47213272MaRDI QIDQ4666658

Sue-Jane Wang, Lu Cui, H. M. James Hung

Publication date: 13 April 2005

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.0006-341x.1999.00853.x

zbMATH Keywords

sample sizepowertype I errorinterim analysis

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Probabilistic models, generic numerical methods in probability and statistics (65C20) Sequential statistical design (62L05)

Related Items (26)

Optimal Conditional Error Functions for the Control of Conditional Power ⋮ Estimation of a Parameter and Its Exact Confidence Interval Following Sequential Sample Size Reestimation Trials ⋮ Finite-Sample Two-Group Composite Hypothesis Testing via Machine Learning ⋮ An evaluation of inferential procedures for adaptive clinical trial designs with pre-specified rules for modifying the sample size ⋮ Seamless phase II/III/IIIb clinical trial designs with different endpoints for different phases ⋮ Distribution theory following blinded and unblinded sample size re-estimation under parametric models ⋮ Methodology and application of adaptive and sequential approaches in contemporary clinical trials ⋮ Sample size optimization and initial allocation of the significance levels in group sequential trials with multiple endpoints ⋮ Design aspects of COVID‐19 treatment trials: Improving probability and time of favorable events ⋮ Adaptive Design and Estimation in Randomized Clinical Trials with Correlated Observations ⋮ Improving the Flexibility and Efficiency of Phase II Designs for Oncology Trials ⋮ Optimal two-stage group-sequential designs ⋮ Comparison of Operating Characteristics of Commonly Used Sample Size Re-Estimation Procedures in a Two-Stage Design ⋮ Adaptive designs for noninferiority trials ⋮ Partition testing in confirmatory adaptive designs with structured objectives ⋮ Interim Analysis and Sample Size Reassessment ⋮ Internal pilots for observational studies ⋮ Impacts on type I error rate with inappropriate use of learn and confirm in confirmatory adaptive design trials ⋮ Adaptive Group Sequential Designs for Clinical Trials: Combining the Advantages of Adaptive and of Classical Group Sequential Approaches ⋮ Self-Designing Two-Stage Trials to Minimize Expected Costs ⋮ Sequential Tests for Noninferiority and Superiority ⋮ Sequential monitoring of response-adaptive randomized clinical trials with sample size re-estimation ⋮ Simulation of clinical trials: a review with emphasis on the design issues ⋮ Exact Confidence Bounds Following Adaptive Group Sequential Tests ⋮ Basic concepts of group sequential and adaptive group sequential test procedures ⋮ Are Flexible Designs Sound?

Cites Work

• Discrete Sequential Boundaries for Clinical Trials
• Stochastically curtailed tests in long–term clinical trials
• Sample size re-estimation without unblinding for normally distributed outcomes with unknown variance
• Designed Extension of Studies Based on Conditional Power

This page was built for publication: Modification of Sample Size in Group Sequential Clinical Trials