Novel global sensitivity analysis methodology accounting for the crucial role of the distribution of input parameters: application to systems biology models

DOI10.1002/RNC.2797MaRDI QIDQ4909331zbMATH OpenOpenAlexWikidataFDO

Authors María Rodríguez-Fernández, Julio R. Banga, Francis J. III Doyle

Publication date 13 March 2013

Published in International Journal of Robust and Nonlinear Control (Search for Journal in Brave)

Full work available at URL http://hdl.handle.net/10261/49061

zbMATH Keywords

parameter estimationrobustnesssystems biologymodel identificationglobal sensitivity analysisparameter distribution

Mathematics Subject Classification ID

Systems biology, networks (92C42) Control/observation systems governed by ordinary differential equations (93C15) Estimation and detection in stochastic control theory (93E10) Identification in stochastic control theory (93E12)

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Cites work

• Algorithm 658
• Derivative based global sensitivity measures and their link with global sensitivity indices
• Global sensitivity analysis: The primer
• Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates
• Making best use of model evaluations to compute sensitivity indices
• Numerical methods and software for sensitivity analysis of differential-algebraic systems
• R. A. Fisher and the making of maximum likelihood 1912--1922
• Scatter search for chemical and bio-process optimization
• Sensitivity Analysis in Practice

Cited in

(14)

• Modeling the inflammatory response in the hypothalamus ensuing heat stroke: iterative cycle of model calibration, identifiability analysis, experimental design and data collection
• The union between structural and practical identifiability makes strength in reducing oncological model complexity: a case study
• Parameter subset selection techniques for problems in mathematical biology
• Crossed-derivative based sensitivity measures for interaction screening
• On the consistency of Sobol indices with respect to stochastic ordering of model parameters
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Topological sensitivity analysis for systems biology
• Sensitivity analysis of signaling pathway models based on discrete-time measurements
• Parametric uncertainty and global sensitivity analysis in a model of the carotid bifurcation: identification and ranking of most sensitive model parameters
• Reaction network models as a tool to study gene regulation and cell signaling in development and diseases
• Sensitivity analysis of microbial growth parameter distributions with respect to data quality and quantity by using Monte Carlo analysis
• Insights of global sensitivity analysis in biological models with dependent parameters
• Robustness of complex feedback systems: application to oncological biochemical networks
• Optimal measurement locations for diagnosis of aortic abnormalities in a lumped-parameter model of the systemic circulation using sensitivity analysis

Describes a project that uses

Uses Software

• PottersWheel
• SBML-SAT
• SensSB
• COPASI
• sbtoolbox
• ODESSA

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