The structure of optimal protocols for a mathematical model of chemotherapy with antiangiogenic effects

DOI10.1137/21M1395326zbMATH Open1486.92084OpenAlexW4224862065MaRDI QIDQ5072294FDOQ5072294

Authors Urszula Ledzewicz, Heinz Schättler 

Publication date 27 April 2022

Published in SIAM Journal on Control and Optimization (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1137/21m1395326

zbMATH Keywords

chemotherapyoptimal controlsingular controlsantiangiogenic treatmentscombination cancer therapies

Mathematics Subject Classification ID

Medical applications (general) (92C50) Optimality conditions for problems involving ordinary differential equations (49K15)

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Cited in

(9)

• Optimal combined radio- and anti-angiogenic cancer therapy
• A mathematical model for the effect of anti-angiogenic therapy in the treatment of cancer tumours by chemotherapy
• A review of optimal chemotherapy protocols: from MTD towards metronomic therapy
• Numerical optimisation of chemotherapy dosage under antiangiogenic treatment in the presence of drug resistance
• Modeling of mouse experiments suggests that optimal anti-hormonal treatment for breast cancer is diet-dependent
• Optimal and suboptimal protocols for a class of mathematical models of tumor anti-angiogenesis
• Realizable protocols for optimal administration of drugs in mathematical models for anti-angiogenic treatment
• Optimal and suboptimal protocols for a mathematical model for tumor anti-angiogenesis in combination with chemotherapy
• Optimal control for a mathematical model for anti-angiogenic treatment with Michaelis-Menten pharmacodynamics

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