A diffuse interface model for cell blebbing including membrane-cortex coupling with linker dynamics

DOI10.1137/21M1433642zbMATH Open1497.92085arXiv2107.06334OpenAlexW3179951643MaRDI QIDQ5092871FDOQ5092871

Authors: Philipp Werner, Martin Burger, Florian Frank, Harald Garcke 

Publication date: 26 July 2022

Published in: SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Abstract: The aim of this paper is to develop suitable models for the phenomenon of cell blebbing, which allow for computational predictions of mechanical effects including the crucial interaction of the cell membrane and the actin cortex. For this sake we resort to a two phase-field model that uses diffuse descriptions of both the membrane and the cortex, which in particular allows for a suitable description of the interaction via linker protein densities. Besides the detailed modelling we discuss some energetic aspects of the models and present a numerical scheme, which allows to carry out several computational studies. In those we demonstrate that several effects found in experiments can be reproduced, in particular bleb formation by cortex rupture, which was not possible by previous models without the linker dynamics.

Full work available at URL: https://arxiv.org/abs/2107.06334

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zbMATH Keywords

fluid-structure interactionphase field modelcell blebbinginteracting interfaces

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Biomechanics (92C10) Cell biology (92C37)

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Cited In (7)

• A PDE model for bleb formation and interaction with linker proteins
• A mathematical model for bleb regulation in zebrafish primordial germ cells
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• Diffusive interface model for actomyosin driven cell oscillations
• A computational model of bleb formation
• Three mechanical models for blebbing and multi-blebbing

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