Limit cycles in piecewise-affine gene network models with multiple interaction loops

DOI10.1080/00207720903144552zbMATH Open1291.34071arXiv0903.1969OpenAlexW2107363444MaRDI QIDQ5168764FDOQ5168764

Authors: Etienne Farcot, Jean-Luc Gouzé 

Publication date: 21 July 2014

Published in: International Journal of Systems Science. Principles and Applications of Systems and Integration (Search for Journal in Brave)

Abstract: In this paper we consider piecewise affine differential equations modeling gene networks. We work with arbitrary decay rates, and under a local hypothesis expressed as an alignment condition of successive focal points. The interaction graph of the system may be rather complex (multiple intricate loops of any sign, multiple thresholds...). Our main result is an alternative theorem showing that, if a sequence of region is periodically visited by trajectories, then under our hypotheses, there exists either a unique stable periodic solution, or the origin attracts all trajectories in this sequence of regions. This result extends greatly our previous work on a single negative feedback loop. We give several examples and simulations illustrating different cases.

Full work available at URL: https://arxiv.org/abs/0903.1969

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zbMATH Keywords

interaction graphmonotonegenetic network modelsconcave maps

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Periodic solutions to ordinary differential equations (34C25) Monotone systems involving ordinary differential equations (34C12)

Cites Work

• Piecewise-linear models of genetic regulatory networks: equilibria and their stability
• Qualitative simulation of the initiation of sporulation in \textit{Bacillus subtilis}
• Qualitative simulation of genetic regulatory networks using piecewise-linear models
• A mathematical framework for the control of piecewise-affine models of gene networks
• Analysis of continuous-time switching networks
• Stable oscillations in mathematical models of biological control systems
• Cooperative systems of differential equations with concave nonlinearities
• Geometric properties of a class of piecewise affine biological network models

Cited In (12)

• Sensitive dependence on initial conditions in gene networks
• Introduction to focus issue: quantitative approaches to genetic networks
• Periodic solutions of gene networks with steep sigmoidal regulatory functions
• Attractors in continuous-time switching networks
• Periodic oscillations for nonmonotonic smooth negative feedback circuits
• A modelling framework for gene regulatory networks including transcription and translation
• Links between topology of the transition graph and limit cycles in a two-dimensional piecewise affine biological model
• Qualitative Behavior of a Metabolic Pathway with Hybrid Feedback
• Cyclic negative feedback systems: what is the chance of oscillation?
• Ramp approximations of sigmoid control functions in gene networks
• Coarse-grained optimization-driven design and piecewise linear modeling of synthetic genetic circuits
• Structural principles for complex dynamics in glass networks

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