Limit cycles in piecewise-affine gene network models with multiple interaction loops

DOI10.1080/00207720903144552MaRDI QIDQ5168764zbMATH OpenOpenAlexFDO

Authors Etienne Farcot, Jean-Luc Gouzé

Publication date 21 July 2014

Published in International Journal of Systems Science. Principles and Applications of Systems and Integration (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0903.1969

zbMATH Keywords

interaction graphmonotonegenetic network modelsconcave maps

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Periodic solutions to ordinary differential equations (34C25) Monotone systems involving ordinary differential equations (34C12)

Abstract: In this paper we consider piecewise affine differential equations modeling gene networks. We work with arbitrary decay rates, and under a local hypothesis expressed as an alignment condition of successive focal points. The interaction graph of the system may be rather complex (multiple intricate loops of any sign, multiple thresholds...). Our main result is an alternative theorem showing that, if a sequence of region is periodically visited by trajectories, then under our hypotheses, there exists either a unique stable periodic solution, or the origin attracts all trajectories in this sequence of regions. This result extends greatly our previous work on a single negative feedback loop. We give several examples and simulations illustrating different cases.

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Cites work

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• Cooperative systems of differential equations with concave nonlinearities
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Cited in

(12)

• Sensitive dependence on initial conditions in gene networks
• Introduction to focus issue: quantitative approaches to genetic networks
• Periodic solutions of gene networks with steep sigmoidal regulatory functions
• Attractors in continuous-time switching networks
• Periodic oscillations for nonmonotonic smooth negative feedback circuits
• A modelling framework for gene regulatory networks including transcription and translation
• Links between topology of the transition graph and limit cycles in a two-dimensional piecewise affine biological model
• Qualitative Behavior of a Metabolic Pathway with Hybrid Feedback
• Cyclic negative feedback systems: what is the chance of oscillation?
• Ramp approximations of sigmoid control functions in gene networks
• Coarse-grained optimization-driven design and piecewise linear modeling of synthetic genetic circuits
• Structural principles for complex dynamics in glass networks

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