Multiple testing with heterogeneous multinomial distributions

DOI10.1111/BIOM.12586MaRDI QIDQ5283311zbMATH OpenOpenAlexWikidataFDO

Authors

Publication date 21 July 2017

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1511.01400

zbMATH Keywords

false discovery rateheterogeneitymultiple hypothesis testingfinite mixture modelmultinomialrhizosphere

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Paired and multiple comparisons; multiple testing (62J15)

Abstract: False discovery rate (FDR) procedures provide misleading inference when testing multiple null hypotheses with heterogeneous multinomial data. For example, in the motivating study the goal is to identify species of bacteria near the roots of wheat plants (rhizobacteria) that are associated with productivity, but standard procedures discover the most abundant species even when the association is weak or negligible, and fail to discover strong associations when species are not abundant. Consequently, a list of abundant species is produced by the multiple testing procedure even though the goal was to provide a list of producitivity-associated species. This paper provides an FDR method based on a mixture of multinomial distributions and shows that it tends to discover more non-negligible effects and fewer negligible effects when the data are heterogeneous across tests. The proposed method and competing methods are applied to the motivating data. The new method identifies more species that are strongly associated with productivity and identifies fewer species that are weakly associated with productivity.

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Cites work

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• scientific article; zbMATH DE number 720689 (Why is no real title available?)
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Cited in

(12)

• Efficient stratified testing procedure for a false discovery rate
• Multivariate Tests Comparing Binomial Probabilities, with Application to Safety Studies for Drugs
• Applying multiple testing procedures to detect change in East African vegetation
• Hypothesis testing for high-dimensional multinomials: a selective review
• A multiple testing protocol for exploratory data analysis and the local misclassification rate
• A non-randomized procedure for large-scale heterogeneous multiple discrete testing based on randomized tests
• Simultaneous Testing of Grouped Hypotheses: Finding Needles in Multiple Haystacks
• LAWS: A Locally Adaptive Weighting and Screening Approach to Spatial Multiple Testing
• Heteroscedasticity-Adjusted Ranking and Thresholding for Large-Scale Multiple Testing
• Multiple hypothesis testing for arbitrarily varying sources
• Testing multiple hypotheses with skewed alternatives
• Controlling the false discovery exceedance for heterogeneous tests

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