Multiple testing with heterogeneous multinomial distributions

DOI10.1111/BIOM.12586zbMATH Open1372.62067arXiv1511.01400OpenAlexW2278602278WikidataQ39418931 ScholiaQ39418931MaRDI QIDQ5283311FDOQ5283311

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Publication date: 21 July 2017

Published in: Biometrics (Search for Journal in Brave)

Abstract: False discovery rate (FDR) procedures provide misleading inference when testing multiple null hypotheses with heterogeneous multinomial data. For example, in the motivating study the goal is to identify species of bacteria near the roots of wheat plants (rhizobacteria) that are associated with productivity, but standard procedures discover the most abundant species even when the association is weak or negligible, and fail to discover strong associations when species are not abundant. Consequently, a list of abundant species is produced by the multiple testing procedure even though the goal was to provide a list of producitivity-associated species. This paper provides an FDR method based on a mixture of multinomial distributions and shows that it tends to discover more non-negligible effects and fewer negligible effects when the data are heterogeneous across tests. The proposed method and competing methods are applied to the motivating data. The new method identifies more species that are strongly associated with productivity and identifies fewer species that are weakly associated with productivity.

Full work available at URL: https://arxiv.org/abs/1511.01400

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zbMATH Keywords

false discovery rateheterogeneitymultiple hypothesis testingfinite mixture modelmultinomialrhizosphere

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Paired and multiple comparisons; multiple testing (62J15)

Cites Work

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Cited In (12)

• Applying multiple testing procedures to detect change in East African vegetation
• Hypothesis testing for high-dimensional multinomials: a selective review
• A multiple testing protocol for exploratory data analysis and the local misclassification rate
• A non-randomized procedure for large-scale heterogeneous multiple discrete testing based on randomized tests
• LAWS: A Locally Adaptive Weighting and Screening Approach to Spatial Multiple Testing
• Heteroscedasticity-Adjusted Ranking and Thresholding for Large-Scale Multiple Testing
• Simultaneous Testing of Grouped Hypotheses: Finding Needles in Multiple Haystacks
• Testing multiple hypotheses with skewed alternatives
• Multiple hypothesis testing for arbitrarily varying sources
• Controlling the false discovery exceedance for heterogeneous tests
• Multivariate Tests Comparing Binomial Probabilities, with Application to Safety Studies for Drugs
• Efficient stratified testing procedure for a false discovery rate

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