The asymptotic distribution of the pathwise mean squared displacement in single particle tracking experiments

DOI10.1111/JTSA.12208MaRDI QIDQ5346580zbMATH OpenOpenAlexFDO

Authors Gustavo Didier, Kui Zhang

Publication date 26 May 2017

Published in Journal of Time Series Analysis (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1507.06567

zbMATH Keywords

fractional Brownian motionviscoelastic fluidanomalous diffusionfractional Ornstein-Uhlenbeck processRosenblatt distributionmean squared displacementmicrorheology

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Fractional processes, including fractional Brownian motion (60G22) Fluid-solid interactions (including aero- and hydro-elasticity, porosity, etc.) (74F10) Physiological flow (92C35) Stochastic methods applied to problems in equilibrium statistical mechanics (82B31)

Abstract: Recent advances in light microscopy have spawned new research frontiers in microbiology by working around the diffraction barrier and allowing for the observation of nanometric biological structures. Microrheology is the study of the properties of complex fluids, such as those found in biology, through the dynamics of small embedded particles, typically latex beads. Statistics based on the recorded sample paths are then used by biophysicists to infer rheological properties of the fluid. In the biophysical literature, the main statistic for characterizing diffusivity is the so-named mean squared displacement (MSD) of the tracer particles. Notwithstanding the central role played by the MSD, its asymptotic distribution in different cases has not yet been established. In this paper, we tackle this problem. We take a pathwise approach and assume that the particle movement undergoes a Gaussian, stationary-increment stochastic process. We show that as the sample and the increment lag sizes go to infinity, the MSD displays Gaussian or non-Gaussian limiting distributions, as well as distinct convergence rates, depending on the diffusion exponent parameter. We illustrate our results analytically and computationally based on fractional Brownian motion and the (integrated) fractional Ornstein-Uhlenbeck process.

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Cited in

(10)

• Asymptotic theory for the detection of mixing in anomalous diffusion
• Reconstructing complex fluid properties from the behavior of fluctuating immersed particles
• The asymptotic distribution of the pathwise mean squared displacement in single particle tracking experiments
• Asymptotic analysis of the mean squared displacement under fractional memory kernels
• The generalized Langevin equation in harmonic potentials: anomalous diffusion and equipartition of energy
• Statistical challenges in microrheology
• Measurement error correction in particle tracking microrheology
• On the wavelet-based simulation of anomalous diffusion
• Fluid heterogeneity detection based on the asymptotic distribution of the time-averaged mean squared displacement in single particle tracking experiments
• A compressed sensing approach to interpolation of fractional Brownian trajectories for a single particle tracking experiment

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