Statistical challenges in microrheology

DOI10.1111/J.1467-9892.2012.00792.XzbMATH Open1282.62232arXiv1201.5984OpenAlexW1957922766MaRDI QIDQ5397947FDOQ5397947

Authors: Gustavo Didier, Scott A. McKinley, David B. Hill, John Fricks 

Publication date: 25 February 2014

Published in: Journal of Time Series Analysis (Search for Journal in Brave)

Abstract: Microrheology is the study of the properties of a complex fluid through the diffusion dynamics of small particles, typically latex beads, moving through that material. Currently, it is the dominant technique in the study of the physical properties of biological fluids, of the material properties of membranes or the cytoplasm of cells, or of the entire cell. The theoretical underpinning of microrheology was given in Mason and Weitz (Physical Review Letters; 1995), who introduced a framework for the use of path data of diffusing particles to infer viscoelastic properties of its fluid environment. The multi-particle tracking techniques that were subsequently developed have presented numerous challenges for experimentalists and theoreticians. This paper describes some specific challenges that await the attention of statisticians and applied probabilists. We describe relevant aspects of the physical theory, current inferential efforts and simulation aspects of a central model for the dynamics of nano-scale particles in viscoelastic fluids, the generalized Langevin equation.

Full work available at URL: https://arxiv.org/abs/1201.5984

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zbMATH Keywords

waveletsGaussian processessimulationfractional processesnon-Newtonian fluidsgeneralized Langevin equationlocal Whittlemicrorheology

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Gaussian processes (60G15) Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Non-Markovian processes: estimation (62M09) Physiological flow (92C35)

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Cited In (15)

• Time-Domain Methods for Diffusive Transport in Soft Matter
• On fractional Lévy processes: tempering, sample path properties and stochastic integration
• Reconstructing complex fluid properties from the behavior of fluctuating immersed particles
• WEAK ERROR RATES FOR OPTION PRICING UNDER LINEAR ROUGH VOLATILITY
• The asymptotic distribution of the pathwise mean squared displacement in single particle tracking experiments
• Asymptotic analysis of the mean squared displacement under fractional memory kernels
• A lubricant boundary condition for a biological body lined by a thin heterogeneous biofilm
• The generalized Langevin equation in harmonic potentials: anomalous diffusion and equipartition of energy
• Fluid-particle dynamics for passive tracers advected by a thermally fluctuating viscoelastic medium
• Measurement error correction in particle tracking microrheology
• Active and passive microrheology: theory and simulation
• On the wavelet-based simulation of anomalous diffusion
• Anomalous diffusion and the generalized Langevin equation
• Fluid heterogeneity detection based on the asymptotic distribution of the time-averaged mean squared displacement in single particle tracking experiments
• Two-step wavelet-based estimation for Gaussian mixed fractional processes

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