Bistability and oscillatory behaviours of cyclic feedback loops

DOI10.1007/S10440-023-00618-XzbMATH Open1524.92042arXiv2304.12801MaRDI QIDQ6089346FDOQ6089346

Authors: Jules Guilberteau 

Publication date: 17 November 2023

Published in: Acta Applicandae Mathematicae (Search for Journal in Brave)

Abstract: In this paper, we study the stability of an Ordinary Differential Equation (ODE) usually referred to as Cyclic Feedback Loop, which typically models a biological network of molecules where each molecule regulates its successor in a cycle. Regulations, which can be either positive or negative, are modelled by increasing or decreasing functions. We make a complete analysis of this model for a wide range of functions (including affine and Hill functions) by determining the parameters for which bistability and oscillatory behaviours arise. These results encompass previous theoretical studies of gene regulatory networks, which are particular cases of this model.

Full work available at URL: https://arxiv.org/abs/2304.12801

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zbMATH Keywords

periodic orbitstability analysismultistabilitygene regulatory networkrepressilatortoggle switch

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42) Nonlinear oscillations and coupled oscillators for ordinary differential equations (34C15)

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Cited In (5)

• Cycle flows and multistability in oscillatory networks
• Self-sustaining positive feedback loops in discrete and continuous systems
• Title not available (Why is that?)
• Positive feedback loops and multistationarity
• Oscillations and bistability in a model of ERK regulation

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