Bistability and oscillatory behaviours of cyclic feedback loops

DOI10.1007/S10440-023-00618-XMaRDI QIDQ6089346zbMATH OpenFDO

Authors Jules Guilberteau

Publication date 17 November 2023

Published in Acta Applicandae Mathematicae (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2304.12801

zbMATH Keywords

periodic orbitstability analysismultistabilitygene regulatory networkrepressilatortoggle switch

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42) Nonlinear oscillations and coupled oscillators for ordinary differential equations (34C15)

Abstract: In this paper, we study the stability of an Ordinary Differential Equation (ODE) usually referred to as Cyclic Feedback Loop, which typically models a biological network of molecules where each molecule regulates its successor in a cycle. Regulations, which can be either positive or negative, are modelled by increasing or decreasing functions. We make a complete analysis of this model for a wide range of functions (including affine and Hill functions) by determining the parameters for which bistability and oscillatory behaviours arise. These results encompass previous theoretical studies of gene regulatory networks, which are particular cases of this model.

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Cites work

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Cited in

(5)

• Cycle flows and multistability in oscillatory networks
• Self-sustaining positive feedback loops in discrete and continuous systems
• scientific article; zbMATH DE number 4051410 (Why is no real title available?)
• Positive feedback loops and multistationarity
• Oscillations and bistability in a model of ERK regulation

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