Efficient methods for sampling spike trains in networks of coupled neurons

DOI10.1214/11-AOAS467zbMATH Open1229.92015arXiv1111.7098MaRDI QIDQ652350FDOQ652350

Authors: Yuriy Mishchenko, Liam Paninski 

Publication date: 14 December 2011

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: Monte Carlo approaches have recently been proposed to quantify connectivity in neuronal networks. The key problem is to sample from the conditional distribution of a single neuronal spike train, given the activity of the other neurons in the network. Dependencies between neurons are usually relatively weak; however, temporal dependencies within the spike train of a single neuron are typically strong. In this paper we develop several specialized Metropolis--Hastings samplers which take advantage of this dependency structure. These samplers are based on two ideas: (1) an adaptation of fast forward--backward algorithms from the theory of hidden Markov models to take advantage of the local dependencies inherent in spike trains, and (2) a first-order expansion of the conditional likelihood which allows for efficient exact sampling in the limit of weak coupling between neurons. We also demonstrate that these samplers can effectively incorporate side information, in particular, noisy fluorescence observations in the context of calcium-sensitive imaging experiments. We quantify the efficiency of these samplers in a variety of simulated experiments in which the network parameters are closely matched to data measured in real cortical networks, and also demonstrate the sampler applied to real calcium imaging data.

Full work available at URL: https://arxiv.org/abs/1111.7098

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zbMATH Keywords

HMMblock-Gibbs samplingfluorescence imaging

Mathematics Subject Classification ID

Monte Carlo methods (65C05) Numerical analysis or methods applied to Markov chains (65C40) Neural biology (92C20)

Cites Work

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Cited In (8)

• Objective and efficient inference for couplings in neuronal network
• Fast inference in generalized linear models via expected log-likelihoods
• A Bayesian approach for inferring neuronal connectivity from calcium fluorescent imaging data
• Sparse sampling: theory, methods and an application in neuroscience
• Control of sampling rate in map-based models of spiking neurons
• A Rate and History-Preserving Resampling Algorithm for Neural Spike Trains
• Consistent estimation of complete neuronal connectivity in large neuronal populations using sparse ``shotgun neuronal activity sampling
• Efficient Markov chain Monte Carlo methods for decoding neural spike trains

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