The distribution of F_st and other genetic statistics for a class of population structure models
From MaRDI portal
Publication:663124
DOI10.1007/S00285-010-0333-0zbMATH Open1303.92073OpenAlexW2963959267WikidataQ51718359 ScholiaQ51718359MaRDI QIDQ663124FDOQ663124
Abstract: We examine genetic statistics used in the study of structured populations. In a 1999 paper, Wakeley observed that the coalescent process associated with the finite island model can be decomposed into a scattering phase and a collecting phase. In this paper, we introduce a class of population structure models, which we refer to as G/KC models, that obey such a decomposition. In a large population, large sample limit we derive the distribution of the statistic Fst for all G/KC models under the assumptions of strong or weak mutation. We show that in the large population, large sample limit the island and two dimensional stepping stone models are members of the G/KC class of models, thereby deriving the distributions of Fst for these two well known models as a special case of a general formula. We show that our analysis of Fst can be extended to an entire class of genetic statistics, and we use our approach to examine homozygosity measures. Our analysis uses coalescent based methods.
Recommendations
- The distribution of \(F_{st}\) for the island model in the large population, weak mutation limit
- Genealogy and subpopulation differentiation under various models of population structure.
- Dynamics of \(F_{st}\) for the island model
- Coalescence times andFSTvalues in subdivided populations with symmetric structure
- Steady state of homozygosity and \(G_{st}\) for the island model
Cites work
- scientific article; zbMATH DE number 3512673 (Why is no real title available?)
- scientific article; zbMATH DE number 3560403 (Why is no real title available?)
- scientific article; zbMATH DE number 1761225 (Why is no real title available?)
- scientific article; zbMATH DE number 1857897 (Why is no real title available?)
- Analysis of Gene Diversity in Subdivided Populations
- Asymptotic results on the length of coalescent trees
- Coalescing random walks and voter model consensus times on the torus in \({\mathbb{Z}}^ d\)
- Genealogy and subpopulation differentiation under various models of population structure.
- Group selection for a polygenic behavioral trait: estimating the degree of population subdivision.
- Line-of-descent and genealogical processes, and their applications in population genetics models
- Mean and variance of \(F_{ST}\) in a finite number of incompletely isolated populations
- Pólya-like urns and the Ewens' sampling formula
- Steady state of homozygosity and \(G_{st}\) for the island model
- The Decay of Genetic Variability in Geographically Structured Populations
- The ages of alleles and a coalescent
- The coalescent
- The distribution of \(F_{st}\) for the island model in the large population, weak mutation limit
- The sampling theory of selectively neutral alleles
- The spatial \(\Lambda\)-coalescent
- The stepping stone model. II: Genealogies and the infinite sites model
- The stepping stone model: New formulas expose old myths
- Two-locus, fourth-order gene frequency moments: Implications for the variance of squared linkage disequilibrium and the variance of homozygosity
Cited in
(13)- A new general analytical approach for modeling patterns of genetic differentiation and effective size of subdivided populations over time
- scientific article; zbMATH DE number 2062253 (Why is no real title available?)
- Steady state of homozygosity and \(G_{st}\) for the island model
- On the transition of genetic differentiation from isolation to panmixia: what we can learn from \(G_{ST}\) and \(D\)
- The sampling theory of neutral alleles in an island population of fluctuating size
- Properties of Weir and Cockerham's \(F_{s t}\) estimators and associated bootstrap confidence intervals
- Statistics of Natural Populations. III. Sequential Sampling Plans for the Estimation of Gene Frequencies
- The distribution of \(F_{st}\) for the island model in the large population, weak mutation limit
- General theory for stochastic admixture graphs and \(F\)-statistics
- Inference from the stationary distribution of allele frequencies in a family of Wright-Fisher models with two levels of genetic variability
- Dynamics of \(F_{st}\) for the island model
- Quasi equilibrium, variance effective size and fixation index for populations with substructure
- Effective size and \(F\)-statistics of subdivided populations for sex-linked loci
This page was built for publication: The distribution of \(F_{st}\) and other genetic statistics for a class of population structure models
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q663124)
