The distribution of F_st and other genetic statistics for a class of population structure models

DOI10.1007/S00285-010-0333-0zbMATH Open1303.92073arXiv0811.1553OpenAlexW2963959267WikidataQ51718359 ScholiaQ51718359MaRDI QIDQ663124FDOQ663124

Authors: Sivan Leviyang 

Publication date: 14 February 2012

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: We examine genetic statistics used in the study of structured populations. In a 1999 paper, Wakeley observed that the coalescent process associated with the finite island model can be decomposed into a scattering phase and a collecting phase. In this paper, we introduce a class of population structure models, which we refer to as G/KC models, that obey such a decomposition. In a large population, large sample limit we derive the distribution of the statistic Fst for all G/KC models under the assumptions of strong or weak mutation. We show that in the large population, large sample limit the island and two dimensional stepping stone models are members of the G/KC class of models, thereby deriving the distributions of Fst for these two well known models as a special case of a general formula. We show that our analysis of Fst can be extended to an entire class of genetic statistics, and we use our approach to examine homozygosity measures. Our analysis uses coalescent based methods.

Full work available at URL: https://arxiv.org/abs/0811.1553

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zbMATH Keywords

coalescentIsland modelStepping Stone model

Mathematics Subject Classification ID

Multivariate distribution of statistics (62H10) Genetics and epigenetics (92D10) Interacting random processes; statistical mechanics type models; percolation theory (60K35)

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Cited In (12)

• Steady state of homozygosity and \(G_{st}\) for the island model
• A new general analytical approach for modeling patterns of genetic differentiation and effective size of subdivided populations over time
• Title not available (Why is that?)
• Inference from the stationary distribution of allele frequencies in a family of Wright-Fisher models with two levels of genetic variability
• Quasi equilibrium, variance effective size and fixation index for populations with substructure
• Effective size and \(F\)-statistics of subdivided populations for sex-linked loci
• Statistics of Natural Populations. III. Sequential Sampling Plans for the Estimation of Gene Frequencies
• On the transition of genetic differentiation from isolation to panmixia: what we can learn from \(G_{ST}\) and \(D\)
• Properties of Weir and Cockerham's \(F_{s t}\) estimators and associated bootstrap confidence intervals
• The distribution of \(F_{st}\) for the island model in the large population, weak mutation limit
• Dynamics of \(F_{st}\) for the island model
• General theory for stochastic admixture graphs and \(F\)-statistics

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