The circular SiZer, inferred persistence of shape parameters and application to early stem cell differentiation

DOI10.3150/15-BEJ722zbMATH Open1349.62195arXiv1404.3300OpenAlexW3102909657WikidataQ58883941 ScholiaQ58883941MaRDI QIDQ726734FDOQ726734

Authors: Kwang-Rae Kim, Axel Munk, Florian Rehfeldt, Max Sommerfeld, Joachim Weickert, Carina Wollnik, Stephan F. Huckemann 

Publication date: 14 July 2016

Published in: Bernoulli (Search for Journal in Brave)

Abstract: We generalize the SiZer of Chaudhuri and Marron (J. Amer. Statist. Assoc. 94 (1999) 807-823, Ann. Statist. 28 (2000) 408-428) for the detection of shape parameters of densities on the real line to the case of circular data. It turns out that only the wrapped Gaussian kernel gives a symmetric, strongly Lipschitz semi-group satisfying "circular" causality, that is, not introducing possibly artificial modes with increasing levels of smoothing. Some notable differences between Euclidean and circular scale space theory are highlighted. Based on this, we provide an asymptotic theory to make inference about the persistence of shape features. The resulting circular mode persistence diagram is applied to the analysis of early mechanically-induced differentiation in adult human stem cells from their actin-myosin filament structure. As a consequence, the circular SiZer based on the wrapped Gaussian kernel (WiZer) allows the verification at a controlled error level of the observation reported by Zemel et al. (Nat. Phys. 6 (2010) 468-473): Within early stem cell differentiation, polarizations of stem cells exhibit preferred directions in three different micro-environments.

Full work available at URL: https://arxiv.org/abs/1404.3300

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zbMATH Keywords

circular datamode huntingvariation diminishingstem cell differentiationcircular scale spacesmultiscale processpersistence inferencewrapped Gaussian kernel estimator

Mathematics Subject Classification ID

Density estimation (62G07) Directional data; spatial statistics (62H11) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

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Cited In (11)

• On geometric probability distributions on the torus with applications to molecular biology
• Torus principal component analysis with applications to RNA structure
• Extremes of spherical fractional Brownian motion
• Recent advances in directional statistics
• Principal component analysis and clustering on manifolds
• A scale space approach for exploring structure in spherical data
• Backward nested descriptors asymptotics with inference on stem cell differentiation
• Quantifying Cellular Pluripotency and Pathway Robustness Through Forman-Ricci Curvature
• Nonparametric estimation of directional highest density regions
• Fire seasonality identification with multimodality tests
• Data analysis on nonstandard spaces

Uses Software

• ftnonpar
• CircSiZer
• SiZer

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