The multivariate Dirichlet-multinomial distribution and its application in forensic genetics to adjust for subpopulation effects using the -correction

DOI10.1016/J.TPB.2015.08.004zbMATH Open1342.92134arXiv1406.6508OpenAlexW1849314370WikidataQ48740861 ScholiaQ48740861MaRDI QIDQ736337FDOQ736337

Torben Tvedebrink, Niels Morling, Poul Svante Eriksen

Publication date: 3 August 2016

Published in: Theoretical Population Biology (Search for Journal in Brave)

Abstract: In this paper, we discuss the construction of a multivariate generalisation of the Dirichlet-multinomial distribution. An example from forensic genetics in the statistical analysis of DNA mixtures motivates the study of this multivariate extension. In forensic genetics, adjustment of the match probabilities due to remote ancestry in the population is often done using the so-called { heta}-correction. This correction increases the probability of observing multiple copies of rare alleles and thereby reduces the weight of the evidence for rare genotypes. By numerical examples, we show how the { heta}-correction incorporated by the use of the multivariate Dirichlet-multinomial distribution affects the weight of evidence. Furthermore, we demonstrate how the { heta}-correction can be incorporated in a Markov structure needed to make efficient computations in a Bayesian network.

Full work available at URL: https://arxiv.org/abs/1406.6508

zbMATH Keywords

forensic genetics\(\theta\)-correctionmultivariate Dirichlet-multinomial distributionSTR DNA mixture

Mathematics Subject Classification ID

Multivariate distribution of statistics (62H10) Applications of statistics to biology and medical sciences; meta analysis (62P10) Estimation in multivariate analysis (62H12) Genetics and epigenetics (92D10)

Cites Work

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• Algorithm AS 159: An Efficient Method of Generating Random R × C Tables with Given Row and Column Totals
• Variable selection for sparse Dirichlet-multinomial regression with an application to microbiome data analysis
• Overdispersion in allelic counts and \(\theta\)-correction in forensic genetics
• Computational aspects of DNA mixture analysis

Uses Software

• R
• AS 159
• DNAmixtures

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