The multivariate Dirichlet-multinomial distribution and its application in forensic genetics to adjust for subpopulation effects using the -correction

DOI10.1016/J.TPB.2015.08.004MaRDI QIDQ736337zbMATH OpenOpenAlexWikidataFDO

Authors Torben Tvedebrink, Poul Svante Eriksen, Niels Morling

Publication date 3 August 2016

Published in Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1406.6508

zbMATH Keywords

forensic genetics\(\theta\)-correctionmultivariate Dirichlet-multinomial distributionSTR DNA mixture

Mathematics Subject Classification ID

Multivariate distribution of statistics (62H10) Applications of statistics to biology and medical sciences; meta analysis (62P10) Estimation in multivariate analysis (62H12) Genetics and epigenetics (92D10)

Abstract: In this paper, we discuss the construction of a multivariate generalisation of the Dirichlet-multinomial distribution. An example from forensic genetics in the statistical analysis of DNA mixtures motivates the study of this multivariate extension. In forensic genetics, adjustment of the match probabilities due to remote ancestry in the population is often done using the so-called { heta}-correction. This correction increases the probability of observing multiple copies of rare alleles and thereby reduces the weight of the evidence for rare genotypes. By numerical examples, we show how the { heta}-correction incorporated by the use of the multivariate Dirichlet-multinomial distribution affects the weight of evidence. Furthermore, we demonstrate how the { heta}-correction can be incorporated in a Markov structure needed to make efficient computations in a Bayesian network.

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Cites work

• scientific article; zbMATH DE number 997340 (Why is no real title available?)
• scientific article; zbMATH DE number 3171497 (Why is no real title available?)
• scientific article; zbMATH DE number 3292503 (Why is no real title available?)
• Algorithm AS 159: An Efficient Method of Generating Random R × C Tables with Given Row and Column Totals
• Computational aspects of DNA mixture analysis
• Overdispersion in allelic counts and \(\theta\)-correction in forensic genetics
• Variable selection for sparse Dirichlet-multinomial regression with an application to microbiome data analysis

Cited in

(1)

• Overdispersion in allelic counts and \(\theta\)-correction in forensic genetics

Describes a project that uses

Uses Software

• DNAmixtures
• AS 159
• R

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