An extended filament based lamellipodium model produces various moving cell shapes in the presence of chemotactic signals
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Publication:739355
DOI10.1016/J.JTBI.2015.06.044zbMATH Open1343.92075arXiv1502.02442OpenAlexW1492329252WikidataQ50880283 ScholiaQ50880283MaRDI QIDQ739355FDOQ739355
Authors: Angelika Manhart, Christian Schmeiser, Nikolaos Sfakianakis, Dietmar Ölz 
Publication date: 18 August 2016
Published in: Journal of Theoretical Biology (Search for Journal in Brave)
Abstract: The Filament Based Lamellipodium Model (FBLM) is a two-phase two-dimensional continuum model, describing the dynamcis of two interacting families of locally parallel actin filaments (C.Schmeiser and D.Oelz, How do cells move? Mathematical modeling of cytoskeleton dynamics and cell migration. Cell mechanics: from single scale-based models to multiscale modeling. Chapman and Hall, 2010). It contains accounts of the filaments' bending stiffness, of adhesion to the substrate, and of cross-links connecting the two families. An extension of the model is presented with contributions from nucleation of filaments by branching, from capping, from contraction by actin-myosin interaction, and from a pressure-like repulsion between parallel filaments due to Coulomb interaction. The effect of a chemoattractant is described by a simple signal transduction model influencing the polymerization speed. Simulations with the extended model show its potential for describing various moving cell shapes, depending on the signal transduction procedure, and for predicting transients between nonmoving and moving states as well as changes of direction.
Full work available at URL: https://arxiv.org/abs/1502.02442
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- The flatness of lamellipodia explained by the interaction between actin dynamics and membrane deformation
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