Some consequences of thermodynamic feasibility for chemical reaction networks. Considering thermodynamic feasibility in current CRN research

DOI10.1007/S10910-021-01231-9MaRDI QIDQ830885zbMATH OpenOpenAlexFDO

Authors G. Neumann

Publication date 10 May 2021

Published in Journal of Mathematical Chemistry (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1403.0241

zbMATH Keywords

chemical reaction networkinjectivityextended detailed balanceloop-less fluxthermodynamic feasible flux

Mathematics Subject Classification ID

Statistical thermodynamics (82B30) Classical flows, reactions, etc. in chemistry (92E20)

Abstract: Power law dynamics is used to describe the stability behavior in metabolic networks such as chemical reaction networks (CRN's). These systems allow multiple steady states within a single stoichiometric class. On the other side thermodynamic constraints such as loop-less fluxes represented by the Gorban theorem of alternatives applied to these networks reveal considerable restrictions to their dynamics by eliminating multistability of CRN's in general. Thermodynamic feasible CRN's are contained in the class of injective CRN's. We can give an alternative proof of the detailed balance with Brewer's Fixed Point Theorem. Furthermore we can derive by the loop-less principle the extended detailed balance. This paper establishes a link between recent research in CRN theory and thermodynamic basics. The result has also consequences for the picture of multiple steady states as assumed for cell differentiation and regulation. CRN's provide from their perspective not enough means to maintain multistability without regulation or external control.

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Cited in

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• Toward a thermodynamic characterization of chemical reaction networks

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