Simulating the process of malignant transformation

DOI10.1016/0025-5564(94)90008-6MaRDI QIDQ1340480zbMATH OpenOpenAlexWikidataFDO

Authors E. G. Luebeck, Suresh Moolgavkar

Publication date 19 December 1994

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(94)90008-6

zbMATH Keywords

likelihood-based methodssimulation of carcinogenesisstochastic growth of malignant tumorstwo-mutation clonal expansion model

Mathematics Subject Classification ID

Probabilistic models, generic numerical methods in probability and statistics (65C20) Medical applications (general) (92C50)

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• Partial differential equations
• Quantitative analysis of two-dimensional observations of premalignant clones in the presence or absence of malignant tumors
• Stochastic models of HIV epidemic in homosexual populations - the effects of mixing patterns
• Two-mutation model for carcinogenesis: Joint analysis of premalignant and malignant lesions

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• Incorporating observability thresholds of tumors into the two-stage carcinogenesis model
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• Fractal and stochastic geometry inference for breast cancer: a case study with random fractal models and quermass-interaction process

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