Simultaneous elastic shape optimization for a domain splitting in bone tissue engineering

DOI10.1098/RSPA.2018.0718MaRDI QIDQ5160706zbMATH OpenOpenAlexWikidataFDO

Authors Patrina S. P. Poh, Martin Rumpf, Stefan Simon, Patrick W. Dondl

Publication date 29 October 2021

Published in Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1809.07555

zbMATH Keywords

applied mathematicsbiomedical engineeringbone microstructurecomputational mathematicselastic shape optimizationhomogenizationphase-field model

Mathematics Subject Classification ID

Biomechanical solid mechanics (74L15) Optimization of other properties in solid mechanics (74P10) Finite element methods applied to problems in solid mechanics (74S05)

Abstract: This paper deals with the simulateneous optimization of a subset $mathcal{O}_0$ of some domain $Omega$ and its complement $mathcal{O}_1=Omegasetminusoverline{mathcalO}_0$ both considered as separate elastic objects subject to a set of loading scenarios. If one asks for a configuration which minimizes the maximal elastic cost functional both phases compete for space since elastic shapes usually get mechanically more stable when being enlarged. Such a problem arises in biomechanics where a bioresorbable polymer scaffold is implanted in place of lost bone tissue and in a regeneration phase new bone tissue grows in the scaffold complement via osteogenesis. In fact, the polymer scaffold should be mechanically stable to bear loading in the early stage regeneration phase and at the same time the new bone tissue grown in the complement of this scaffold should as well bear the loading. Here, this optimal subdomain splitting problem with appropriate elastic cost functionals is introduced and existence of optimal two phase configurations is established for a regularized formulation. Furthermore, based on a phase field approximation a finite element discretization is derived. Numerical experiments are presented for the design of optimal periodic scaffold microstructure.

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Cited in

(4)

• Branching structures in elastic shape optimization
• Analyzing and optimizing bone scaffolds
• An efficient model for scaffold mediated bone regeneration
• Sharp-interface limit of a multi-phase spectral shape optimization problem for elastic structures

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