Stability and optimal control of a delayed HIV model

DOI10.1002/MMA.4207MaRDI QIDQ4637711zbMATH OpenOpenAlexWikidataFDO

Authors Diana Rocha, Delfim F. M. Torres, Cristiana J. Silva

Publication date 25 April 2018

Published in Mathematical Methods in the Applied Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1609.07654

zbMATH Keywords

HIV modelingincubation and pharmacological time delaysoptimal controlstability

Mathematics Subject Classification ID

Stability theory of functional-differential equations (34K20) Qualitative investigation and simulation of models involving functional-differential equations (34K60) Optimality conditions for problems involving ordinary differential equations (49K15) Medical epidemiology (92C60) Epidemiology (92D30)

Abstract: We propose and investigate a delayed model that studies the relationship between HIV and the immune system during the natural course of infection and in the context of antiviral treatment regimes. Sufficient criteria for local asymptotic stability of the infected and viral free equilibria are given. An optimal control problem with time delays both in state variables (incubation delay) and control (pharmacological delay) is then formulated and analyzed, where the objective consists to find the optimal treatment strategy that maximizes the number of uninfected $CD{4}^{+}$ T cells as well as CTL immune response cells, keeping the drug therapy as low as possible.

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