Stabilizing gene regulatory networks through feedforward loops

DOI10.1063/1.4808248MaRDI QIDQ2787862zbMATH OpenOpenAlexWikidataFDO

Authors C. Kadelka, David Murrugarra, Reinhard Laubenbacher

Publication date 4 March 2016

Published in Chaos (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1304.8077, http://hdl.handle.net/10919/24398

zbMATH Keywords

Boolean networksfeedforward loopsgene regulatory networksmicroRNAs

Mathematics Subject Classification ID

Systems biology, networks (92C42) Genetics and epigenetics (92D10) Stochastic stability in control theory (93E15)

Abstract: The global dynamics of gene regulatory networks are known to show robustness to perturbations in the form of intrinsic and extrinsic noise, as well as mutations of individual genes. One molecular mechanism underlying this robustness has been identified as the action of so-called microRNAs that operate via feedforward loops. We present results of a computational study, using the modeling framework of stochastic Boolean networks, which explores the role that such network motifs play in stabilizing global dynamics. The paper introduces a new measure for the stability of stochastic networks. The results show that certain types of feedforward loops do indeed buffer the network against stochastic effects.

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Cites work

• Robustness and evolvability in genetic regulatory networks
• Wagner's canalization model

Cited in

(13)

• The influence of assortativity on the robustness of signal-integration logic in gene regulatory networks
• Chaotic gene regulatory networks can be robust against mutations and noise
• Buffering gene expression noise by microRNA based feedforward regulation
• A feedforward loop motif in transcriptional regulation: induction and repression
• On the stability of nucleic acid feedback control systems
• Superstability of the yeast cell-cycle dynamics: ensuring causality in the presence of biochemical stochasticity
• The contribution of microRNA-mediated regulation to short- and long-term gene expression predictability
• Introduction to focus issue: quantitative approaches to genetic networks
• Feedback-induced complex dynamics in a two-component regulatory circuit
• A general mechanism for network-dosage compensation in gene circuits
• Stabilizing and Destabilizing Effects of Embedding 3-Node Subgraphs on the State Space of Boolean Networks
• Controllability of asynchronous Boolean multiplex control networks
• The NF-κ B network as an example of a regulatory network with a positive and negative feedback loop

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