An algebraic approach to signaling cascades with \(n\) layers

DOI10.1007/s11538-011-9658-0zbMath1244.92015arXiv1008.0431OpenAlexW2135162433WikidataQ51574915 ScholiaQ51574915MaRDI QIDQ417317

Michael Knudsen, Carsten Wiuf, Elisenda Feliu, Lars Nørvang Andersen

Publication date: 14 May 2012

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1008.0431

zbMATH Keywords

rational functionsmass action kineticsfutile cycleposttranslational modificationsequestrationstimulus-response

Mathematics Subject Classification ID

Biomedical imaging and signal processing (92C55) Dynamical systems in biology (37N25) Biochemistry, molecular biology (92C40) Cell biology (92C37) General theory for ordinary differential equations (34A99)

Related Items (12)

The steady-state degree and mixed volume of a chemical reaction network ⋮ Realistic enzymology for post-translational modification: zero-order ultrasensitivity revisited ⋮ A discrete dynamical system approach to pathway activation profiles of signaling cascades ⋮ Joining and decomposing reaction networks ⋮ Implicit dose-response curves ⋮ Variable elimination in post-translational modification reaction networks with mass-action kinetics ⋮ Regions of multistationarity in cascades of Goldbeter-Koshland loops ⋮ The effect of site-to-site variability in ultrasensitive dose responses ⋮ Monostationarity and multistationarity in tree networks of Goldbeter-Koshland loops ⋮ Exact analysis of intrinsic qualitative features of phosphorelays using mathematical models ⋮ Sign-sensitivities for reaction networks: an algebraic approach ⋮ MAPK's networks and their capacity for multistationarity due to toric steady states

Cites Work

• On the number of steady states in a multiple futile cycle
• The rational parameterisation theorem for multisite post-translational modification systems
• Translation-invariant monotone systems, and a global convergence result for enzymatic futile cycles
• Multistationarity in the activation of a MAPK: parametrizing the relevant region in parameter space
• Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible
• Multiple Equilibria in Complex Chemical Reaction Networks: Semiopen Mass Action Systems
• Introduction to Applied Nonlinear Dynamical Systems and Chaos
• Multiple Equilibria in Complex Chemical Reaction Networks: I. The Injectivity Property
• Multiple Equilibria in Complex Chemical Reaction Networks: II. The Species-Reaction Graph

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