Mathematical modeling of antibody drug conjugates with the target and tubulin dynamics to predict AUC
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Publication:1649441
DOI10.1016/j.jtbi.2018.01.028zbMath1397.92275OpenAlexW2792992934WikidataQ50153374 ScholiaQ50153374MaRDI QIDQ1649441
Publication date: 6 July 2018
Published in: Journal of Theoretical Biology (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1016/j.jtbi.2018.01.028
half-lifearea under the curve (AUC)monoclonal antibodies (mAbs)pharmacokinetics and pharmacodynamics (PKPD)target mediated drug disposition (TMDD)
Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40) Global stability of solutions to ordinary differential equations (34D23)
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Cites Work
- Dynamics of target-mediated drug disposition: how a drug reaches its target
- Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting \textit{in vivo} potency
- A mathematical analysis of rebound in a target-mediated drug disposition model. I: Without feedback