A Simple Technique to Evaluate Model Sensitivity in the Continual Reassessment Method

DOI10.1111/j.0006-341X.2002.00671.xzbMath1210.62149WikidataQ74784779 ScholiaQ74784779MaRDI QIDQ3079010

Rick Chappell, Ying-Kuen Cheung

Publication date: 1 March 2011

Published in: Biometrics (Search for Journal in Brave)

zbMATH Keywords

continual reassessment methodindifference intervalmodel sensitivity

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Sequential statistical design (62L05)

Related Items (10)

Optimal sequential designs in phase I studies ⋮ Unnamed Item ⋮ Stochastic approximation and modern model-based designs for dose-finding clinical trials ⋮ Continual reassessment and related dose-finding designs ⋮ A note on the robustness of the continual reassessment method ⋮ Adaptive clinical trial designs for phase I cancer studies ⋮ Continual reassessment method with multiple toxicity constraints ⋮ On the consistency of the continual reassessment method with multiple toxicity constraints ⋮ The treatment versus experimentation dilemma in dose finding studies ⋮ Dose Finding for Continuous and Ordinal Outcomes with a Monotone Objective Function: A Unified Approach

Cites Work

• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Design and Analysis of Phase I Clinical Trials
• Consistency of continual reassessment method under model misspecification
• Continual Reassessment Method: A Likelihood Approach
• A Curve‐Free Method for Phase I Clinical Trials
• Sequential Designs for Phase I Clinical Trials with Late‐Onset Toxicities

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