Graphical characterizations of robust stability in biological interaction networks
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Abstract: Previous studies have inferred robust stability of reaction networks by utilizing linear programs or iterative algorithms. Such algorithms become tedious or computationally infeasible for large networks. In addition, they operate like black-boxes without offering intuition for the structures that are necessary to maintain stability. In this work, we provide several graphical criteria for constructing robust stability certificates, checking robust non-degeneracy, {verifying persistence}, and establishing global stability. By characterizing a set of stability-preserving graph modifications that includes the enzymatic modification motif, we show that the stability of arbitrarily large nonlinear networks can be examined by simple visual inspection. We show applications of this technique to ubiquitous motifs in systems biology such as Post-Translational Modification (PTM) cycles, the Ribosome Flow Model (RFM), T-cell kinetic proofreading and others.
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Cited in
(5)- Structure and stability of certain chemical networks and applications to the kinetic proofreading model of T-cell receptor signal transduction
- Dynamical robustness and its structural dependence in biological networks
- The circuit-breaking algorithm for monotone systems
- Robust stability and instability of biochemical networks with parametric uncertainty
- Graphical requirements for multistationarity in reaction networks and their verification in BioModels
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