Optimal planning of adaptive two-stage designs

DOI10.1002/SIM.8953MaRDI QIDQ6628099zbMATH OpenFDO

Authors Maximilian Pilz, Kevin Kunzmann, C. Herrmann, Geraldine Rauch, Meinhard Kieser

Publication date 29 October 2024

Published in Statistics in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial 4.0 International

Full work available at URL https://doi.org/10.1002/SIM.8953

zbMATH Keywords

adaptive designclinical trialoptimal designsample size calculation

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

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Cited in

(6)

• Point estimation, confidence intervals, and P-values for optimal adaptive two-stage designs with normal endpoints
• Optimal adaptive promising zone designs
• Optimization of the two-stage group sequential three-arm gold-standard design for non-inferiority trials
• New results on optimal conditional error functions for adaptive two-stage designs
• Comments on: ``Sample size adaptation designs and efficiency comparison with group sequential designs
• Swarm-Based Search Procedure for Finding Optimal Multi-Stage Designs for Phase II Clinical Trials

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