Angle-based joint and individual variation explained
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Publication:130628
DOI10.1016/J.JMVA.2018.03.008zbMATH Open1408.62113arXiv1704.02060OpenAlexW2605944716WikidataQ130070141 ScholiaQ130070141MaRDI QIDQ130628FDOQ130628
Meilei Jiang, Qing Feng, J. S. Marron, J.S. Marron, Jan Hannig, Qing Feng, Meilei Jiang
Publication date: July 2018
Published in: Journal of Multivariate Analysis (Search for Journal in Brave)
Abstract: Integrative analysis of disparate data blocks measured on a common set of experimental subjects is a major challenge in modern data analysis. This data structure naturally motivates the simultaneous exploration of the joint and individual variation within each data block resulting in new insights. For instance, there is a strong desire to integrate the multiple genomic data sets in The Cancer Genome Atlas to characterize the common and also the unique aspects of cancer genetics and cell biology for each source. In this paper we introduce Angle-Based Joint and Individual Variation Explained capturing both joint and individual variation within each data block. This is a major improvement over earlier approaches to this challenge in terms of a new conceptual understanding, much better adaption to data heterogeneity and a fast linear algebra computation. Important mathematical contributions are the use of score subspaces as the principal descriptors of variation structure and the use of perturbation theory as the guide for variation segmentation. This leads to an exploratory data analysis method which is insensitive to the heterogeneity among data blocks and does not require separate normalization. An application to cancer data reveals different behaviors of each type of signal in characterizing tumor subtypes. An application to a mortality data set reveals interesting historical lessons. Software and data are available at GitHub <https://github.com/MeileiJiang/AJIVE_Project>.
Full work available at URL: https://arxiv.org/abs/1704.02060
Factor analysis and principal components; correspondence analysis (62H25) Applications of statistics to biology and medical sciences; meta analysis (62P10)
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Cited In (25)
- Multiview cluster aggregation and splitting, with an application to multiomic breast cancer data
- A survey of high dimension low sample size asymptotics
- Decomposition of Variation of Mixed Variables by a Latent Mixed Gaussian Copula Model
- Hierarchical nuclear norm penalization for multi-view data integration
- High-Dimensional Factor Regression for Heterogeneous Subpopulations
- Group linear non-Gaussian component analysis with applications to neuroimaging
- Jackstraw inference for AJIVE data integration
- CDPA: common and distinctive pattern analysis between high-dimensional datasets
- Comments on ``Data science, big data and statistics
- Joint and individual analysis of breast cancer histologic images and genomic covariates
- Percolate: an exponential family JIVE model to design DNA-based predictors of drug response
- Covariate‐driven factorization by thresholding for multiblock data
- Sparse and integrative principal component analysis for multiview data
- AJIVE
- Title not available (Why is that?)
- sJIVE: supervised joint and individual variation explained
- Simultaneous non-Gaussian component analysis (SING) for data integration in neuroimaging
- Analysis of joint shape variation from multi-object complexes
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- Double-Matched Matrix Decomposition for Multi-View Data
- D-CCA: A Decomposition-Based Canonical Correlation Analysis for High-Dimensional Datasets
- RaJIVE
- Persistent topology of protein space
- Functional random effects modeling of brain shape and connectivity
- Perturbed factor analysis: accounting for group differences in exposure profiles
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