Forward and backward evolutionary processes and allele frequency spectrum in a cancer cell population

DOI10.1016/j.tpb.2017.08.006zbMath1393.92035OpenAlexW2750778855MaRDI QIDQ1746103

Hideki Innan, Hisashi Ohtsuki

Publication date: 24 April 2018

Published in: Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.tpb.2017.08.006

zbMATH Keywords

population geneticscancercoalescent theorybranching theoryallele frequency spectrum

Mathematics Subject Classification ID

Problems related to evolution (92D15) Applications of branching processes (60J85) Medical applications (general) (92C50) Genetics and epigenetics (92D10)

Related Items (4)

Mutation frequencies in a birth-death branching process ⋮ An accurate approximation for the expected site frequency spectrum in a Galton-Watson process under an infinite sites mutation model ⋮ Discrete coalescent trees ⋮ Exact site frequency spectra of neutrally evolving tumors: a transition between power laws reveals a signature of cell viability

Cites Work

• Dynamics of cancer recurrence
• A note on distributions of times to coalescence, under time-dependent population size
• The coalescent
• Ancestral inference in population genetics
• Properties of a neutral allele model with intragenic recombination
• Statistical properties of segregating sites
• Population genetics of neutral mutations in exponentially growing cancer cell populations
• Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability
• The age of a mutation in a general coalescent tree
• Large population solution of the stochastic Luria–Delbrück evolution model
• Branching Process Models of Cancer
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