The geometry of spontaneous spiking in neuronal networks

DOI10.1007/S00332-012-9125-6zbMATH Open1257.34036arXiv1105.2801OpenAlexW3099763076MaRDI QIDQ1928239FDOQ1928239

Authors: Georgi S. Medvedev, Svitlana Zhuravytska 

Publication date: 2 January 2013

Published in: Journal of Nonlinear Science (Search for Journal in Brave)

Abstract: The mathematical theory of pattern formation in electrically coupled networks of excitable neurons forced by small noise is presented in this work. Using the Freidlin-Wentzell large deviation theory for randomly perturbed dynamical systems and the elements of the algebraic graph theory, we identify and analyze the main regimes in the network dynamics in terms of the key control parameters: excitability, coupling strength, and network topology. The analysis reveals the geometry of spontaneous dynamics in electrically coupled network. Specifically, we show that the location of the minima of a certain continuous function on the surface of the unit n-cube encodes the most likely activity patterns generated by the network. By studying how the minima of this function evolve under the variation of the coupling strength, we describe the principal transformations in the network dynamics. The minimization problem is also used for the quantitative description of the main dynamical regimes and transitions between them. In particular, for the weak and strong coupling regimes, we present asymptotic formulas for the network activity rate as a function of the coupling strength and the degree of the network. The variational analysis is complemented by the stability analysis of the synchronous state in the strong coupling regime. The stability estimates reveal the contribution of the network connectivity and the properties of the cycle subspace associated with the graph of the network to its synchronization properties. This work is motivated by the experimental and modeling studies of the ensemble of neurons in the Locus Coeruleus, a nucleus in the brainstem involved in the regulation of cognitive performance and behavior.

Full work available at URL: https://arxiv.org/abs/1105.2801

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zbMATH Keywords

noisepattern formationsynchronizationnetwork topologyneuronal networkexcitable system

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Neural biology (92C20) Neural networks for/in biological studies, artificial life and related topics (92B20) Nonlinear oscillations and coupled oscillators for ordinary differential equations (34C15) Synchronization of solutions to ordinary differential equations (34D06) Ordinary differential equations and systems with randomness (34F05) Bifurcation of solutions to ordinary differential equations involving randomness (34F10)

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Cited In (15)

• Stability of twisted states in the Kuramoto model on Cayley and random graphs
• Optimal Control for Fast, Accurate Threshold-Hitting
• Uniform-in-Time Continuum Limit of the Winfree Model on an Infinite Cylinder and Emergent Dynamics
• A global bifurcation organizing rhythmic activity in a coupled network
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• Degree assortativity in networks of spiking neurons
• Shaping bursting by electrical coupling and noise
• The nonlinear heat equation on \(W\)-random graphs

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