Multiscale modelling of fibres dynamics and cell adhesion within moving boundary cancer invasion
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Publication:2002103
DOI10.1007/S11538-019-00598-WzbMATH Open1417.92029OpenAlexW2893044096WikidataQ93067857 ScholiaQ93067857MaRDI QIDQ2002103FDOQ2002103
Authors: Robyn Shuttleworth, Dumitru Trucu 
Publication date: 11 July 2019
Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)
Abstract: Cancer cell invasion is recognised as one of the hallmarks of cancer and involves several inner-related multiscale processes that ultimately contribute to its spread into the surrounding tissue. In order to gain a deeper understanding of the tumour invasion process, we pay special attention to the interacting dynamics between the cancer cell population and various constituents of the surrounding tumour microenvironment. To that end, we consider the key role that ECM plays within the human body tissue, providing not only structure and support to surrounding cells, but also acting as a platform for cells communication and spatial movement. There are several other vital structures within the ECM, however we are going to focus primarily on fibrous proteins, such as fibronectin. These fibres play a crucial role in tumour progression, enabling the anchorage of tumour cells to the ECM. In this work we consider the two-scale dynamic cross-talk between cancer cells and a two component ECM (consisting of both a fibre and a non-fibre phase). To that end, we incorporate the interlinked two-scale dynamics of cells-ECM interactions within the tumour support that contributes simultaneously both to cell-adhesion and to the dynamic rearrangement and restructuring of the ECM fibres. Furthermore, this is embedded within a multiscale moving boundary approach for the invading cancer cell population, in the presence of cell-adhesion at the tissue scale and cell-scale fibre redistribution activity and leading edge matrix degrading enzyme molecular proteolytic processes. The overall modelling framework will be accompanied by computational results that will explore the impact on cancer invasion patterns of different levels of cell adhesion in conjunction with the continuous ECM fibres rearrangement.
Full work available at URL: https://arxiv.org/abs/1810.00785
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Computational methods for problems pertaining to biology (92-08) Cell movement (chemotaxis, etc.) (92C17)
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Cited In (23)
- Exponential dichotomies for nonlocal differential operators with infinite range interactions
- Mathematical modelling of cancer invasion: a review
- Inverse reconstruction of cell proliferation laws in cancer invasion modelling
- Pattern formation and front stability for a moving-boundary model of biological invasion and recession
- The effect of geometry on survival and extinction in a moving-boundary problem motivated by the Fisher-KPP equation
- Non-local multiscale approaches for tumour-oncolytic viruses interactions
- Front stability of infinitely steep travelling waves in population biology
- Intracellular modelling of cell-matrix adhesion during cancer cell invasion
- Inverse problem approaches for mutation laws in heterogeneous tumours with local and nonlocal dynamics
- Matrix adhesion and remodeling diversifies modes of cancer invasion across spatial scales
- A model of the effects of cancer cell motility and cellular adhesion properties on tumour-immune dynamics
- Traction patterns of tumor cells
- Survival, extinction, and interface stability in a two-phase moving boundary model of biological invasion
- On a multiscale model involving cell contractivity and its effects on tumor invasion
- Adhesion mechanisms in cancer metastasis
- A Genuinely Hybrid, Multiscale 3D Cancer Invasion and Metastasis Modelling Framework
- Nonlocal multiscale modelling of tumour-oncolytic viruses interactions within a heterogeneous fibrous/non-fibrous extracellular matrix
- Directionality of macrophages movement in tumour invasion: a multiscale moving-boundary approach
- A level-set approach for a multi-scale cancer invasion model
- Modelling the role of cell-cell adhesion in the growth and development of carcinomas
- Cell-scale degradation of peritumoural extracellular matrix fibre network and its role within tissue-scale cancer invasion
- Non-local multiscale approach for the impact of go or grow hypothesis on tumour-viruses interactions
- Multiscale dynamics of a heterotypic cancer cell population within a fibrous extracellular matrix
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