Optimal control of a fractional order epidemic model with application to human respiratory syncytial virus infection

DOI10.1016/J.CHAOS.2018.10.021zbMATH Open1442.92180arXiv1810.06900OpenAlexW2896702456WikidataQ60224146 ScholiaQ60224146MaRDI QIDQ2201401FDOQ2201401

Delfim F. M. Torres, Silvério S. Rosa

Publication date: 29 September 2020

Published in: Chaos, Solitons and Fractals (Search for Journal in Brave)

Abstract: A human respiratory syncytial virus surveillance system was implemented in Florida in 1999, to support clinical decision-making for prophylaxis of premature newborns. Recently, a local periodic SEIRS mathematical model was proposed in [Stat. Optim. Inf. Comput. 6 (2018), no.1, 139--149] to describe real data collected by Florida's system. In contrast, here we propose a non-local fractional (non-integer) order model. A fractional optimal control problem is then formulated and solved, having treatment as the control. Finally, a cost-effectiveness analysis is carried out to evaluate the cost and the effectiveness of proposed control measures during the intervention period, showing the superiority of obtained results with respect to previous ones.

Full work available at URL: https://arxiv.org/abs/1810.06900

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zbMATH Keywords

fractional optimal controlcompartmental mathematical modelshuman respiratory syncytial virus (HRSV)

Mathematics Subject Classification ID

Epidemiology (92D30) Fractional ordinary differential equations (34A08) Numerical methods based on necessary conditions (49M05)

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Cited In (25)

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