Local controllability and optimal control for a model of combined anticancer therapy with control delays

DOI10.3934/mbe.2017013zbMath1351.93018WikidataQ50544120 ScholiaQ50544120MaRDI QIDQ335260

Helmut Maurer, Andrzej Swierniak, Jerzy Klamka

Publication date: 2 November 2016

Published in: Mathematical Biosciences and Engineering (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.3934/mbe.2017013

zbMATH Keywords

discretization; optimal control; optimality conditions; nonlinear programming; local controllability; combined cancer therapy; control delays

Mathematics Subject Classification ID

65K05: Numerical mathematical programming methods

90C30: Nonlinear programming

65K10: Numerical optimization and variational techniques

93B05: Controllability

49N90: Applications of optimal control and differential games

49M37: Numerical methods based on nonlinear programming

37N25: Dynamical systems in biology

92C50: Medical applications (general)

49J15: Existence theories for optimal control problems involving ordinary differential equations

93C15: Control/observation systems governed by ordinary differential equations

49M25: Discrete approximations in optimal control

49K15: Optimality conditions for problems involving ordinary differential equations

Uses Software

• AMPL
• Ipopt