On drug resistance and metronomic chemotherapy: a mathematical modeling and optimal control approach
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optimal controlcancer chemotherapydrug resistancemetronomic chemotherapysingular controlstumor heterogeneity
Medical applications (general) (92C50) Existence theories for optimal control problems involving ordinary differential equations (49J15) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving ordinary differential equations (49K15) Optimality conditions for problems involving partial differential equations (49K20) Applications of optimal control and differential games (49N90) Application models in control theory (93C95)
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Cites work
- scientific article; zbMATH DE number 3191476 (Why is no real title available?)
- A 3-compartment model for chemotherapy of heterogeneous tumor populations
- AntiAngiogenic Therapy in Cancer Treatment as an Optimal Control Problem
- Calculus of variations and optimal control theory. A concise introduction
- Cancer chemotherapy optimization under evolving drug resistance.
- Drug resistance in cancer chemotherapy as an optimal control problem
- Dynamical properties of a minimally parameterized mathematical model for metronomic chemotherapy
- Dynamics and control of a mathematical model for metronomic chemotherapy
- Geometric optimal control. Theory, methods and examples
- Introduction to the mathematical theory of control
- Minimizing long-term tumor burden: the logic for metronomic chemotherapeutic dosing and its antiangiogenic basis
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- On optimal chemotherapy for heterogeneous tumors
- On the MTD paradigm and optimal control for multi-drug cancer chemotherapy
- Optimal control for mathematical models of cancer therapies. An application of geometric methods
- Optimal control of a mathematical model for cancer chemotherapy under tumor heterogeneity
- Populational adaptive evolution, chemotherapeutic resistance and multiple anti-cancer therapies
- Singular controls and chattering arcs in optimal control problems arising in biomedicine
- Singular trajectories and their role in control theory
- The impact of cell density and mutations in a model of multidrug resistance in solid tumors
- Treatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injections
- Tumor cells proliferation and migration under the influence of their microenvironment
- Using mathematical modeling as a resource in clinical trials
Cited in
(21)- A mathematical justification for metronomic chemotherapy in oncology
- A review of optimal chemotherapy protocols: from MTD towards metronomic therapy
- Drug resistance in cancer chemotherapy as an optimal control problem
- Efficiency of cancer treatments: \textit{in silico experiments}
- Theoretical modeling of collaterally sensitive drug cycles: shaping heterogeneity to allow adaptive therapy
- On the MTD paradigm and optimal control for multi-drug cancer chemotherapy
- An adaptive pharmacokinetic optimal control approach in chemotherapy for heterogeneous tumor
- scientific article; zbMATH DE number 1419523 (Why is no real title available?)
- Evaluating the efficacies of maximum tolerated dose and metronomic chemotherapies: a mathematical approach
- Ultimate dynamics and optimal control of a multi-compartment model of tumor resistance to chemotherapy
- Optimization of an \textit{in vitro} chemotherapy to avoid resistant tumours
- On minimising tumoural growth under treatment resistance
- A mathematical model to study low-dose metronomic scheduling for chemotherapy
- Dynamical properties of a minimally parameterized mathematical model for metronomic chemotherapy
- The effect of heterogeneity on optimal regimens in cancer chemotherapy
- Capitalizing on competition: an evolutionary model of competitive release in metastatic castration resistant prostate cancer treatment
- On optimal chemotherapy for heterogeneous tumors
- Optimal control in reducing side effects during and after chemotherapy of solid tumors
- Maximum tolerated dose versus metronomic scheduling in the treatment of metastatic cancers
- Modelling bistable tumour population dynamics to design effective treatment strategies
- Do mechanisms matter? Comparing cancer treatment strategies across mathematical models and outcome objectives
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