On drug resistance and metronomic chemotherapy: a mathematical modeling and optimal control approach
DOI10.3934/MBE.2017014zbMATH Open1351.49049OpenAlexW2531093247WikidataQ50544115 ScholiaQ50544115MaRDI QIDQ335265FDOQ335265
Authors: Heinz Schättler, Nicolas André, Marie Amélie Heng, Eddy Pasquier, Urszula Ledzewicz, Shuo Wang 
Publication date: 2 November 2016
Published in: Mathematical Biosciences and Engineering (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.3934/mbe.2017014
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optimal controlcancer chemotherapydrug resistancemetronomic chemotherapysingular controlstumor heterogeneity
Medical applications (general) (92C50) Existence theories for optimal control problems involving ordinary differential equations (49J15) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving ordinary differential equations (49K15) Optimality conditions for problems involving partial differential equations (49K20) Applications of optimal control and differential games (49N90) Application models in control theory (93C95)
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- On optimal chemotherapy for heterogeneous tumors
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Cited In (20)
- Drug resistance in cancer chemotherapy as an optimal control problem
- Efficiency of cancer treatments: \textit{in silico experiments}
- On the MTD paradigm and optimal control for multi-drug cancer chemotherapy
- An adaptive pharmacokinetic optimal control approach in chemotherapy for heterogeneous tumor
- Dynamical properties of a minimally parameterized mathematical model for metronomic chemotherapy
- Optimal control in reducing side effects during and after chemotherapy of solid tumors
- A mathematical model to study low-dose metronomic scheduling for chemotherapy
- Title not available (Why is that?)
- The effect of heterogeneity on optimal regimens in cancer chemotherapy
- A mathematical justification for metronomic chemotherapy in oncology
- Evaluating the efficacies of maximum tolerated dose and metronomic chemotherapies: a mathematical approach
- Theoretical modeling of collaterally sensitive drug cycles: shaping heterogeneity to allow adaptive therapy
- Modelling bistable tumour population dynamics to design effective treatment strategies
- Maximum tolerated dose versus metronomic scheduling in the treatment of metastatic cancers
- Optimization of an \textit{in vitro} chemotherapy to avoid resistant tumours
- Capitalizing on competition: an evolutionary model of competitive release in metastatic castration resistant prostate cancer treatment
- A review of optimal chemotherapy protocols: from MTD towards metronomic therapy
- Ultimate dynamics and optimal control of a multi-compartment model of tumor resistance to chemotherapy
- On optimal chemotherapy for heterogeneous tumors
- Do mechanisms matter? Comparing cancer treatment strategies across mathematical models and outcome objectives
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