Biased estimates of treatment effect in randomized experiments with nonlinear regressions and omitted covariates

DOI10.1093/BIOMET/71.3.431zbMATH Open0565.62094OpenAlexW2006623746MaRDI QIDQ3680149FDOQ3680149

Authors: Mitchell H. Gail, Harry S. Wieand, Steven T. Piantadosi 

Publication date: 1984

Published in: Biometrika (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1093/biomet/71.3.431

Recommendations

• scientific article; zbMATH DE number 2195397
• scientific article; zbMATH DE number 1304754
• Exact expressions for the weights used in least-squares regression estimation for the log-logistic and Weibull distribution
• Relating Cox's Proportional Hazard Model to the Exponential Model for Survival
• scientific article; zbMATH DE number 1096544
• Robust design in a two treatment comparison in the presence of a covariate
• Joint distribution of simultaneous exposures to several carcinogens in a case–control study: sample size determination
• The likelihood ratio test for detecting the best treatment among several exponential populations
• Estimation of the Lundberg coefficient for a Markov modulated risk model

zbMATH Keywords

clinical trialsrandomizationmethod of momentsasymptotic biasmaximum likelihood estimatesomitted covariatescensored exponential survival dataexponential regressionsunbiased treatment estimates

Mathematics Subject Classification ID

General nonlinear regression (62J02) Linear regression; mixed models (62J05) Applications of statistics to biology and medical sciences; meta analysis (62P10) Monte Carlo methods (65C05)

Cited In (79)

• Propensity-score matching with competing risks in survival analysis
• Principled selection of baseline covariates to account for censoring in randomized trials with a survival endpoint
• Influence of trial duration on the bias of the estimated treatment effect in clinical trials when individual heterogeneity is ignored
• Measuring and Estimating Treatment Effect on Count Outcome in Randomized Trial and Observational Studies
• Correction of confounding bias in non-randomized studies by appropriate weighting
• Binary Regression in Truncated Samples, with Application to Comparing Dietary Instruments in a Large Prospective Study
• Closed Testing with Globaltest, with Application in Metabolomics
• The impacts of unobserved covariates on covariate-adaptive randomized experiments
• Effect of Covariate Omission in Randomised Controlled Trials: A Review and Simulation Study
• Impact of misspecifying spatial exposures in a generalized additive modeling framework: with application to the study of the dynamics of Comandra blister rust in British Columbia
• Assessing the performance of population adjustment methods for anchored indirect comparisons: a simulation study
• Survival analysis using a 5-step stratified testing and amalgamation routine (5-STAR) in randomized clinical trials
• Target estimands for efficient decision making: response to comments on ``Assessing the performance of population adjustment methods for anchored indirect comparisons: a simulation study
• Another look at the method of Y-standardization in logit and probit models
• Target estimands for population-adjusted indirect comparisons
• Inverse probability of treatment weighting with generalized linear outcome models for doubly robust estimation
• Direct effect and indirect effect on an outcome under nonlinear modeling
• Some approximations to the path formula for some nonlinear models
• Fifty years with the Cox proportional hazards regression model
• A stochastic model to analyse risk factors for emesis in multi-cycle chemotherapies
• Cox regression can be collapsible and aalen regression can be non-collapsible
• Efficiency comparison of methods for estimation in longitudinal regression models
• Two-stage residual inclusion for survival data and competing risks -- an instrumental variable approach with application to SEER-medicare linked data
• Robust inference for the proportional hazards model with two-phase cohort sampling data
• A nonparametric test for diagnosis of the proportionality assumption
• Validity of tests under covariate-adaptive biased coin randomization and generalized linear models
• Least squares type estimation for Cox regression model and specification error
• Average effects based on regressions with a logarithmic link function: a new approach with stochastic covariates
• Correcting the results of the wrong model: treatment effects under early detection of cancer
• High dimensional variable selection with clustered data: an application of random multivariate survival forests for detection of outlier medical device components
• Increasing the power: a practical approach to goodness-of-fit test for logistic regression models with continuous predictors
• Effect of covariate omission in Weibull accelerated failure time model: a caution
• The covariance adjustment approaches for combining incomparable Cox regressions caused by unbalanced covariates adjustment: a multivariate meta-analysis study
• Maximum-likelihood estimation and presentation for the interaction between treatments in observational studies with a dichotomous outcome
• Survival analysis with time-varying regression effects using a tree-based approach
• Wei, Lin and Weissfeld's marginal analysis of multivariate failure time data
• Confounding and collapsibility in causal inference
• Calibrating sensitivity analyses to observed covariates in observational studies
• Measuring and estimating the interaction between exposures on a dichotomous outcome for observational studies
• A partial score test for difference among heterogeneous populations
• Bias in gee estimates from misspecified models for longitudinal data
• Analysis of Failure Time Data with Multilevel Clustering, with Application to the Child Vitamin A Intervention Trial in Nepal
• Exogenous treatment and endogenous factors: vanishing of omitted variable bias on the interaction term
• The effects of covariate adjustment in generalized linear models
• A Tutorial on Multilevel Survival Analysis: Methods, Models and Applications
• Randomization-based nonparametric methods for the analysis of multicentre trials
• Randomization-based nonparametric methods for the analysis of multicentre trials
• Effects of omitting a covariate in poisson models when the data are balanced
• The Performance of Two Data-Generation Processes for Data with Specified Marginal Treatment Odds Ratios
• The indirect method: inference based on intermediate statistics -- a synthesis and examples
• Omitted variable bias in GLMs of neural spiking activity
• Estimation and interpretation of models of absolute risk from epidemiologic data, including family-based studies
• Sam Wieand at the University of Pittsburgh
• Sam Wieand (1944--2006)
• Robust Alternatives to ANCOVA for Estimating the Treatment Effect via a Randomized Comparative Study
• Estimating and contextualizing the attenuation of odds ratios due to non collapsibility
• Inference for proportional hazard model with propensity score
• Survival Analysis in Clinical Trials: Past Developments and Future Directions
• Point and Interval Estimations of Marginal Risk Difference by Logistic Model
• On proportional hazards assumption under the random effects models
• Relatives' risks: Frailty models of life history data
• Identification of confounding versus dispersing covariates by confounding influence
• Calculating the power or sample size for the logistic and proportional hazards models
• Simpson's paradox in survival models
• Estimating a Marginal Causal Odds Ratio Subject to Confounding
• Accounting for matching structure in post-matching analysis of observational studies
• Impact of covariate omission and categorization from the Fine-Gray model in randomized-controlled trials
• Quantifying the Impact of Unobserved Heterogeneity on Inference from the Logistic Model
• The role of conditional likelihoods in latent variable modeling
• Bias and sensitivity analysis when estimating treatment effects from the Cox model with omitted covariates
• Does Home Health Care Increase the Probability of 30-Day Hospital Readmissions? Interpreting Coefficient Sign Reversals, or Their Absence, in Binary Logistic Regression Analysis
• EFFECT OF MISSING AN INFLUENTIAL COVARIATE
• The potential for bias in principal causal effect estimation when treatment received depends on a key covariate
• Group sequential tests for treatment effect on survival and cumulative incidence at a fixed time point
• Meta-analysis methodology for combining treatment effects from Cox proportional hazard models with different covariate adjustments
• Effect of censoring on adjusting for covariates in comparison of survival times
• Balancing Unobserved Covariates With Covariate-Adaptive Randomized Experiments
• Point and interval estimation of baseline risk and treatment effect based on logistic model for observational studies
• NONPARAMETRIC ANALYSIS OF COVARIANCE FOR HYPOTHESIS TESTING WITH LOGRANK AND WILCOXON SCORES AND SURVIVAL-RATE ESTIMATION IN A RANDOMIZED CLINICAL TRIAL

This page was built for publication: Biased estimates of treatment effect in randomized experiments with nonlinear regressions and omitted covariates

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q3680149)