Unstable patterns in reaction-diffusion model of early carcinogenesis

DOI10.1016/J.MATPUR.2012.09.011zbMATH Open1295.35072arXiv1104.3592OpenAlexW2000898702MaRDI QIDQ390809FDOQ390809

Authors: Anna Marciniak-Czochra, Grzegorz Karch, Kanako Suzuki 

Publication date: 9 January 2014

Published in: Journal de Mathématiques Pures et Appliquées. Neuvième Série (Search for Journal in Brave)

Abstract: Motivated by numerical simulations showing the emergence of either periodic or irregular patterns, we explore a mechanism of pattern formation arising in the processes described by a system of a single reaction-diffusion equation coupled with ordinary differential equations. We focus on a basic model of early cancerogenesis proposed by Marciniak-Czochra and Kimmel [Comput. Math. Methods Med. {�f 7} (2006), 189--213], [Math. Models Methods Appl. Sci. {�f 17} (2007), suppl., 1693--1719], but the theory we develop applies to a wider class of pattern formation models with an autocatalytic non-diffusing component. The model exhibits diffusion-driven instability (Turing-type instability). However, we prove that all Turing-type patterns, {it i.e.,} regular stationary solutions, are unstable in the Lyapunov sense. Furthermore, we show existence of discontinuous stationary solutions, which are also unstable.

Full work available at URL: https://arxiv.org/abs/1104.3592

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zbMATH Keywords

Neumann boundary conditiondiffusion-driven instabilityPDE-ODE systemTuring type instability

Mathematics Subject Classification ID

Pattern formations in context of PDEs (35B36) Initial-boundary value problems for second-order parabolic systems (35K51) Reaction-diffusion equations (35K57) Developmental biology, pattern formation (92C15)

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