Dynamics of growth and signaling along linear and surface structures in very early tumors

DOI10.1080/10273660600969091MaRDI QIDQ883756zbMATH OpenOpenAlexFDO

Authors Anna Marciniak-Czochra, Marek Kimmel

Publication date 12 June 2007

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Full work available at URL https://eudml.org/doc/230597

zbMATH Keywords

Atypical adenomatous hyperplasia (AAH)Bronchoalveolar carcinoma (BAC)Cancer modellingPattern formationReaction-diffusion equationsSpike solutions

Mathematics Subject Classification ID

Developmental biology, pattern formation (92C15) Medical applications (general) (92C50)

Review text

Summary: There exists evidence that in early stages tumors progress along linear, tubular, or irregular surface structures. This seems to be the case for atypical adenomatous hyperplasia (AAH), a precursor of adenocarcinoma of the lung. We previously published a simplified model, which showed that early structures had a potential towards spontaneous invasive growth following a latency phase. The transition was facilitated by diffusion of a growth factor and nonlinear cell cycle regulation in cancer cells. The mechanism is analogous to that in Turing pattern formation, although the patterns are irregular and unstable. We introduce more biologically justifiable signaling, in which only the free growth factor molecules diffuse. Flexible nonlinearities in the model accommodate several growth patterns of cells as well as internal versus external production of the growth factor. We show that the reaction-diffusion setup results in complicated spike-like solutions. We discuss these results in the light of published data on the AAH.

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