Padé approximants and exact two-locus sampling distributions

DOI10.1214/11-AAP780zbMATH Open1242.65017arXiv1107.3897WikidataQ42161770 ScholiaQ42161770MaRDI QIDQ417074FDOQ417074

Yun S. Song, Paul A. Jenkins

Publication date: 13 May 2012

Published in: The Annals of Applied Probability (Search for Journal in Brave)

Abstract: For population genetics models with recombination, obtaining an exact, analytic sampling distribution has remained a challenging open problem for several decades. Recently, a new perspective based on asymptotic series has been introduced to make progress on this problem. Specifically, closed-form expressions have been derived for the first few terms in an asymptotic expansion of the two-locus sampling distribution when the recombination rate $ho$ is moderate to large. In this paper, a new computational technique is developed for finding the asymptotic expansion to an arbitrary order. Computation in this new approach can be automated easily. Furthermore, it is proved here that only a finite number of terms in the asymptotic expansion is needed to recover (via the method of Pad'{e} approximants) the exact two-locus sampling distribution as an analytic function of $ho$; this function is exact for all values of $hoin[0,infty)$. It is also shown that the new computational framework presented here is flexible enough to incorporate natural selection.

Full work available at URL: https://arxiv.org/abs/1107.3897

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zbMATH Keywords

asymptotic expansionnumerical examplespopulation geneticssampling distributionrecombinationPadé approximants

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sampling theory, sample surveys (62D05) Asymptotic distribution theory in statistics (62E20) Genetics and epigenetics (92D10) Problems related to evolution (92D15)

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Cited In (4)

• Approximate sampling formulae for general finite-alleles models of mutation
• The neutral frequency spectrum of linked sites
• Asymptotic sampling distributions made easy: loose linkage in the ancestral recombination graph
• Closed-form asymptotic sampling distributions under the coalescent with recombination for an arbitrary number of loci

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