Padé approximants and exact two-locus sampling distributions

DOI10.1214/11-AAP780MaRDI QIDQ417074zbMATHWikidataFDO

Authors Paul A. Jenkins, Yun S. Song

Publication date 13 May 2012

Published in The Annals of Applied Probability (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1107.3897

zbMATH Keywords

asymptotic expansionnumerical examplespopulation geneticssampling distributionrecombinationPadé approximants

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sampling theory, sample surveys (62D05) Asymptotic distribution theory in statistics (62E20) Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Abstract: For population genetics models with recombination, obtaining an exact, analytic sampling distribution has remained a challenging open problem for several decades. Recently, a new perspective based on asymptotic series has been introduced to make progress on this problem. Specifically, closed-form expressions have been derived for the first few terms in an asymptotic expansion of the two-locus sampling distribution when the recombination rate $ho$ is moderate to large. In this paper, a new computational technique is developed for finding the asymptotic expansion to an arbitrary order. Computation in this new approach can be automated easily. Furthermore, it is proved here that only a finite number of terms in the asymptotic expansion is needed to recover (via the method of Pad'{e} approximants) the exact two-locus sampling distribution as an analytic function of $ho$; this function is exact for all values of $hoin[0,infty)$. It is also shown that the new computational framework presented here is flexible enough to incorporate natural selection.

Recommendations

• Closed-form asymptotic sampling distributions under the coalescent with recombination for an arbitrary number of loci
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Cites work

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Cited in

(4)

• Approximate sampling formulae for general finite-alleles models of mutation
• The neutral frequency spectrum of linked sites
• Closed-form asymptotic sampling distributions under the coalescent with recombination for an arbitrary number of loci
• Asymptotic sampling distributions made easy: loose linkage in the ancestral recombination graph

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